Cell Language Theory, The: Connecting Mind And Matter

330 The Cell Language Theory: Connecting Mind and Matter

b2861 The Cell Language Theory: Connecting Mind and Matter “6x9”

X and an FDA-approved drug (e.g., Figure 7.18). If the R^2 > 0.60,

discard X; otherwise, continue to the next step.

(4) Plot the SM of each group vs. the drug-induced changes in the

slope of the A vs. C plots (Figure 7.20) for both X and an FDA-

approved drug. If the correlation coefficient of the plot for X is equal

to or greater than that of an FDA-approved drug, the PDE-based

search for anticancer drugs has been successfully completed.

7.3.5 Conserved Transcriptional Response to Cancer (CTRC): The

First Law of Transcriptomics

Figure 7.4 clearly demonstrates that there exists a conserved pattern of

changes in the mRNA levels of budding yeast cells when subjected to

nutritional stress. That is, the glucose–galactose shift causes the Transcript

Level (TL) of most genes to decrease during the first 2–3 h (presumably

because yeast cells cannot metabolize galactose due to lack of galactose-

metabolizing enzymes whose induction takes 2–3 h). In other words, the

intracellular mRNA levels can act as sensitive indicators for the metabolic

state of budding yeast cells. We can generalize this finding to other cell

types and other perturbations, including mechanical, chemical, and mental

(in the case of multicellular organisms with central nervous systems),

leading to the following statement:

The intracellular levels of mRNA molecules can be utilized to monitor

the functional states of living cells in unicellular or multicellular

organisms. (7.31)

It seems necessary to distinguish two kinds of patterns of mRNA

levels: (i) raw (or shallow) patterns as exemplified in Figures 7.4 and 7.17

which are revealed with little or no computational processing of raw mRNA

data and (ii) hidden (or deep) patterns as exemplified in Figures 7.18–7.22

which are made explicit only after often complex mathematical processing

(e.g., using PDE).

Thus, the validity of Statement (7.31) can be said to be empirically

established and may be confidently referred to as the First Principle of

Transcriptomics (FPT), which may turn out to be analogous to the First

Law of Thermodynamics.

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