Cell Language Theory, The: Connecting Mind And Matter

338 The Cell Language Theory: Connecting Mind and Matter

b2861 The Cell Language Theory: Connecting Mind and Matter “6x9”

shown in Figure 8.3(d) was successfully simulated using the PDE,

Eq. (8.3), as evident in Figure 8.3(e). It is interesting to note that a double

exponential function, Eq. (8.7), used in [124], can also simulate the same

histogram, with more or less equal effectiveness, although PDE seems to

perform slightly better as indicated by its smaller root mean square devia-

tion (RMSD) value, i.e., 14.80 vs. 15.53 (see Figures 8.3(e) and (f).

y = A(e–Bx – e–Cx), (8.7)

where A, B, and C are free parameters.

8.2.2 Explanation: Quantization of Energy Levels in Enzymes

Just as the fitting of the blackbody radiation spectra to PRE (Planckian

Distribution Equation) is synonymous with the quantization of the energy

levels of electrons in an atom, so it may be concluded that the fitting of

the single-molecule enzyme turnover times to PDE (as demonstrated in

Figure 8.3(e)) may imply the discretization of the conformational states

of an enzyme molecule, in agreement with the concept of “conforma-

tional substrates” of Frauenfelder et al. [125, 126] and the quantization

of the Gibbs free energy levels of an enzyme. This idea is schematically

represented in Figure 8.4.

Blackbody radiation involves promoting the energy levels (vibra-

tional, electronic, or vibronic) of oscillators from their ground state, E 0 , to

higher energy levels, E 1 through E 6. The wavelength of the radiation (or

quantum) absorbed or emitted is given by DE = Ei - E 0 = hu, where Ei is

the ith excited-state energy level, h is the Planck constant, u is the fre-

quency, and DE is the energy absorbed when an oscillator is excited from

its ground state to the ith energy level. Blackbody radiation results when

electrons transition from one energy level to a lower energy level within

matter, e.g., from E 1 to E 0 , from E 2 to E 0 , etc.

A single molecule of cholesterol oxidase is postulated to exist in n

distinct conformational states (i.e., conformational substrates of

Frauenfelder et al. [125]), denoted as Ci with i running from 1 to n. Each

conformational state (or conformer) is thought to exist in a unique Gibbs

free energy level, carries a set of sequence-specific conformational strains

(or conformons) [25, Chapters 8 and 11], and can be excited to a common

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