Cell Language Theory, The: Connecting Mind And Matter

350 The Cell Language Theory: Connecting Mind and Matter

b2861 The Cell Language Theory: Connecting Mind and Matter “6x9”

points (0, 5, 120, 360, 450, and 85 min) after glucose–galactose shift,

generating over 30,000 mRNA level data points. Of these data, 2159

mRNA levels were chosen arbitrarily and grouped into 250 bins to gener-

ate a histogram shown in Figure 8.6(d). As can be seen in this figure, the

histogram fits the Planckian distribution almost exactly. One of the many

conclusions that can be drawn from this observation is that the mRNA

levels found in budding yeast under the nutritional stress are not random

but organized likely in both space and time.

8.3.5 RNA Levels in Human Breast Tissues (Figure 8.6(e))

Perou et al. [306] measured the mRNA levels of 8102 genes in the nor-

mal human breast cells, and the breast cancer tissues before and after

treating with the anticancer drug, doxorubicin, in 20 breast cancer

patients. Of the 8102 genes, we analyzed 4740 genes and their tran-

scripts. A total of 4740 × 20 = 94,800 mRNA levels were divided into

60 bins to generate a histogram shown in Figure 8.6(e). Again the experi-

mental curve fitted the PDE almost exactly. It is significant that PDE fits

mRNA data measured from both unicellular (yeast) and multicellular

systems (human breast tissues), indicating that PDE captures the basic

molecular mechanisms common to both systems, which is most likely

the molecular mechanisms underlying enzyme catalysis and hence the

SID–TEM–TOF mechanism (i.e., Figure 8.5(b)).

8.3.6 Human T-cell Receptor Variable Region Sequence

Diversity (Figure 8.6(f))

The T-cell receptor consists of two chains — a and b — and each chain

in turn consists of the transmembrane, constant, and variable regions. The

variable regions of T-cell receptors, called CDR3 (complement determin-

ing region 3), recognize pathogens and initiate an immune response. The

CDR3 gene length between conserved residues ranges from 20 to 80

nucleotides. Murugan et al. [476] analyzed the nucleotide sequence data

of T-cell beta chain CDR3 regions obtained from nine human subjects,

each subject generating on average 232,000 unique CDR3 sequences. The

germline DNA encoding the beta chain of human T-cell receptors has 48

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