Key Terms and Concepts 37“6x9” b2861 The Cell Language Theory: Connecting Mind and Matterof what Ling called “induction”. If this interpretation is right, Ling’s
concepts of association and induction may be considered as closely
related to the theory of ligandinduced conformation changes of pro
teins or allosterism proposed by Monod et al. [103], (see also Section
3.2.10).
Apparently it was Ling in the early 1960s [1] who, as a logical conse
quence of his AIH, first postulated that water molecules inside the living
cell are not free and randomly distributed as then (and even now) widely
thought but mostly organized into polarized layers as a result of binding
to (or being “associated” with) charged groups on proteins. AIH has many
aspects, some of them being highly controversial (e.g., the denial of the
role of the membrane pumps in the asymmetric distribution of ions across
cell membrane [105]), resulting in the wholesale rejection of AIH by
many contemporary biologists [107].
It is interesting to note that the question of whether or not the
asymmetric distribution of ions across the cell membrane can be accounted
for entirely based on AIH is still debated among biologists [3, 108]. The
available evidence indicates to me that the asymmetric ion (and other sol
ute) distributions across biomembranes result from a combination of both
passive distributions driven by ion binding to proteins (in agreement with
AIH) and active distributions driven by ATPdependent specific ion pumps
embedded in biomembranes (in disagreement with AIH) and that the for
mer can be identified with equilibrium structures and the latter with dis-
sipative structures of Prigogine (see Section 2.6). Despite this seeming
deficiency, I think AIH has made a major theoretical contribution to estab
lishing the idea that the water molecules inside the living cell may be
organized in a dynamic manner essential for carrying out the basic func
tions of living cells. This view seems to have gained indirect support from
recent experimental findings (e.g., the discovery of the fourth phase of
water [108] and water memory [109]) and the concept of “coherence
domains” in water predicted by quantum field theory [110, 365].2.13 The Fourth-Phase Water
It appears that Pollack and his coworkers [5, 108, 111] have discovered
a new phase of water, i.e., the fourth phase after the solid, liquid, andb2861_Ch-02.indd 37 17-10-2017 11:39:04 AM