Cell Language Theory, The: Connecting Mind And Matter

42 The Cell Language Theory: Connecting Mind and Matter

b2861 The Cell Language Theory: Connecting Mind and Matter “6x9”

named the physical principle responsible for this phenomenon the

Franck–Condon principle (FCP) [70]. I generalized FCP to formulate the

generalized Franck–Condon principle (GFCP) in 1974 [12], which was

also called the PSFP in 1991 [7], and applied it to explain the mechanism

of enzyme catalysis in molecular biology [12], drug–receptor interactions

in pharmacology [25], and biological evolution [7]. Most recently, it was

proposed that protein folding implicates the resonance interactions

between proteins and the hydration shells surrounding proteins [520]. In

all these cases, water structures (or the coherence domains of Del Guidice

et al. [110, 364]) constitute the environment, except that, in catalysis, the

conformational changes of proteins are thought to be preceded by hydra­

tion shell re­arrangements and hence even here water is involved as

environment.

The controversial results of the BMEs shown in Figure 2.11 may be

rationally accounted for if we apply the systome approach as shown

below:

(i) In A, the test tube contains systomes consisting of the complemen­

tary pairing between DNA fragments, D (as systems, S), and their

hydration shells (as environment, E). These pairs will be denoted as

D–E systomes.

(ii) The D–E systomes are in equilibrium with unbound D and E, each

carrying unique structural information. In other words, the hydration

shells of DNA carry as much structural information as DNA itself,

since, according to the systome concept, E and D are on an equal

footing in terms of structures and functions.

(iii) The E components of the D–E systomes transfer their structural

information to the coherence domains of water present in test tube B

through resonance interactions, thereby generating E’s in B which

may be dynamic and unstable but are in equilibrium with their more

stable counterparts. This is possible because, according to Del

Guidice et al. [110, 364], coherence domains can exist in two states,

the stable ground states and the transient excited states.

(iv) The stable version of E present in test tube B can serve as the tem­

plates for the synthesis of DNA fragments upon adding nucleotides

and enzymes, thus regenerating the original DNA fragments in C.

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