Cell Language Theory, The: Connecting Mind And Matter

66 The Cell Language Theory: Connecting Mind and Matter

b2861 The Cell Language Theory: Connecting Mind and Matter “6x9”

Fig

ure 3.7

The EMC model of the respiratory control in mitochondria [129, p. 552]. (a)

A schematic representation of the oxygen

consumption by a mitochondrial suspension upon adding ADP due to the initiation of the endergonic phosphorylation of ADP to form ATP catalyzed by the ETC–PTC–F

F 0

–ATP synthase complex called the supermolecule (see 1

Fig

ures 3.4 and 3.5) or the “oxphosome”

(see Table 3.5). The metabolic states of the mitochondrial suspension before and after adding ADP are referred to as State 4 and State

3, respectively. When the mitochondrial suspension runs out of ADP, the respiratory rate returns to that of State

4. (b) Substrate SH

(^2)
in State A is thought to be oxidized to form S in State B, wherein the two electrons and two protons originating from SH
are separated 2
locally within the ETC (symbolized by the rectangle) but not yet combined at C to form CH
in State C. State B is metastable and has 2
a great tendency to transition to State C but is prevented from doing so by the high activation free energy barrier for the transition from B to C in the absence of ADP (see the solid line).
ADP
State
4
State
3
State
4
time
[O
] 2
AB
C
(a)
(b)
CO
NH 2
3

• +NH

CO 3

2

CO

• 2

CO

• 2 CO
  
  
  • 2
    NH
  
  
  
  

3

+

NH

3

+

+ H ‡∆G

>>

RT

∆G

‡≡ A

CTIV

ATION FREE ENERGY

• (
  ADP+Pi)

+ (

ADP+Pi)

REA

CTION COORDINA

TE

FREE ENERGY^0

C

C

SS

SH

2

CH

2

+ H

• e^


• CO 2 – e
  ++NH

NH 3

3

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