Genetics of Apoptosis

localization 63–3
endoplasmic reticulum 63–1
sequestration at non-mitochondrial
sites 64–3
mammalian members 90
in mitochondria 124–20, 128–3
mouse genetic models 52
nonlethal cell pathways and fates 66–5
proapoptotic functions different designs
55–5
different designs 55–5
homooligomers and pores 54–3
membrane permeability 53, 56–6
yeast models 52–1
protein domain structure 125
Bcl-xL 16, 17, 31, 51, 65
inhibitors 61
mutational studies 60
BCMA 77
bFTZ-F1 43
Bfl-1/A1 16, 17
BH3-domain-only proteins 42, 103–104,
21, 129, 130
BI-l 141
BID 126, 127, 128, 130
BIK 115, 130
cleavage and function, caspase-8
regulation of 11–12, 42, 44
phosphorylation and cleavage, regulation
by casein kinases I and II 11–12
sequestration at non-mitocondrial sites
64–2
sequestration by Bcl-xL 12
BIK 115, 130
Bim (paclitaxel) 65, 130
Binl 227–18
BIR domain 71, 89
brefeldin A 64, 100, 101
Broad-Complex (BR-C) 43

C2 ceramide 109
C6 ceramide 109
c-Abl 103
Caenorhabditis 150
Caenorhabditis elegans, apoptosis in 38, 160–
75, 233
Bcl-2 homolog in 91

BH protein homolog 49

caspase mutations 44

CED-3 32, 33, 89, 168–4

CED-4 143, 168–4

CED-4 adapter 41

ced-4 mutants 46

CED-9 41–42, 168–4

cell identification during somatic

development 160–6

cell identification in the germ line 161–7

cep-1 in 175

CSP-1 and CSP-2 in 34

DNS damage checkpoint pathways in

173

egl-1, ced-3, ced-4 and ced-9 in 166–2

EGL-1 168–4

engulfment genes for dying cells 176–4

genetic pathway 166–1, 166

germ-line cell death 172–70

identification and quantification 163–9

modulators and downstream

components 170–5

potential functions 181–5

rad-5 in 174–9

regulation in specific cell types 171–6

steps in 165

Calane Smith syndrome 24

calmyin 117

calpains 101, 217, 219

calsenilin 117

cancer

alternative death pathways 227–18

new therapies 228–19

Candida albicans 148

casien kinases I and II 15

BID phosphorylation and cleavage by

11–12

CASH (c-FLIP) 11, 18, 81

Casp-8 94

Casp-10 94

caspase-activate DNase (CAD) 43–2

caspase adaptors, knockout of 46–5

caspase recruitment domain (CARD) 6, 33,

34, 69, 82–84

proteins 84

caspase-1 (interleukin- 1b-converting

enzyme) 32, 83

caspase-2 (Nedd2) 32, 34, 40–8

306 GENETICS OF APOPTOSIS