Genetics of Apoptosis

mutation 44–3
caspase-3 6, 7, 40, 44
caspase-6 3
caspase-7 6, 101–8
caspase-8 (procaspace-8; FLICE; MACH) 4–
6, 8 , 44, 81
activation by FLIPs 40
activation of 37–6
activation of caspase-3 6
regulation of BID cleavage and function
11–12
regulation by FLICE-inhibitory proteins
(FLIPs) 10–11
caspase-8/FLICE inhibitor see c-FLIP
caspase-8-mediated cleavage of BID 6–8
caspase-9 6, 7
caspase-9/Apaf1 complex 7
caspase-10, role in death receptor-induced
apoptosis 8
caspase-12 100–8, 104
mutation 45
caspase-independent cell death 210–23, 217
death receptors as triggers 221–12
mitochondrial control 221–16
noncaspase proteases 217–11, 219
signaling in 216–16
caspase-mediated cleavage
of antiapoptotic proteins 19–20
of Bcl-2, Bcl-xL and IAPs 20
caspases 1–3
activation 36–8
activation by death receptors 3–8
activation by oligomerization 37
definition 32
inhibition of 12–14
inhibitors 87–5
mutations and gene knockouts 44–4
regulation of activation 40–43
regulation by Bcl-2 family 41–42
regulation by IAPs 40–9
regulation by transcription 42–1
structure 34
substrate specificity 34–4
targets 43–2
types 32–3
CASPER 11, xviii, 18, 81
CASPY caspase 84
cathepsin B 217

cathepsin D 203, 217

cathepsin L 217

cathepsins 217–10

CD95 see Fas

CD95L see FasL

CED-3 32

ced-3 gene 32

CED-4 93

CED-9 41–42, 93

cell-culture systems 197–210

gene isolation 199–9

correlative strategy 199–3, 201

selection strategies 203–6

screening strategy 206–9, 210

ceramide 144

c-FLIP (CASH, MRIT, CLARP, CASPER,

I-FLICE, usurpin) 11, 18, 81

CHOP (GADD153) 100

c-IAPs 17

cIAP-1 12, 14, 41, 89

cIAP-2 12, 14, 41, 89

cIap2 gene 17

CIDE-A 207

CIDE-B 207

c-Jun amino terminal kinase see JNK

CLARP 11, 18, 81

Cnidaria, cell death in 151

colchicine 151

corpse removal 226–17

CRADD 82

creatine kinase 121

cryopyrin 84

CsA 56, 109

cyclophilin D 121

cysteine-rich extracellular domains (CRDs)

1 , 77

cystine aspartate proteasesseecaspases

cytochrome c 6, 71, 96, 110, 138, 139, 159

cytolethal distending toxins (CDTs) 146

DAP-genes 203

DAP-3 gene 203, 204

DAP-5 gene 203, 204

DAP-kinase 78, 203–4

dark 43

Daxx 221

Dcr3 75

INDEX 307