Genetics of Apoptosis

death domain (DD) 1, 69, 77, 78–6
inhibition by silencer of death domains
(SODD) 10
proteins 79
death effector domain (DED) 4, 10, 34, 69,
69–8, 82
death-inducing signaling complex (DISC) 4–
6, 38, 77–4
death ligands 1, 74–3
death receptor-induced apoptosis
activation of immune and inflammatory
responses 21
augmentation in AIDS 24
autoimmune disorders 24
deletion of thymocytes and peripheral T
cells 21–1
disorders resulting from deregulation of
23–3
establishment of zones of immune
privilage 23
expression of death and decoy receptors
9–10
induction of cell death by cytotoxic T
cells and NK cells 23
instruction apoptosis of B cells 22–2
maintenance of lymphocyte homeostatis
21–2
regulation of 8–20
death receptor-induced apoptosis—
continued
regulation of immune response 20–23
role in development 24–4
role in immune system 20–24
of tumor cells 25–9
death receptors in response to
anticancer therapy 26–7
death receptors/ligands in surveillance
25–5
targeting death receptors for treatment
29–9
death receptors xviii, 1, 3, 74–3
activation f caspases by 3–8
expression of 18–19
induction of apoptosis by 1–8
in response of tumor cells to anticancer
therapy 26–7
in tumor surveillance 25–5

DR3 (Apo3, WSL-1, TRAMP, LARD)

1, 6

DR4 6

DR5 6

DR6 1, 77

decoy receptors 9–10

DcR1 (TRAIL-R3, TRID, LIT) 9, 10, 30

DcR2 (TRAIL-R4, TRUNDD) 9–10,

29,30

DcR3 10

DEVD-AMC 153, 154, 156

DEVD-FMK 153

diap1 43

DIAP1 185, 187–80

diap2 43

DIAP2 187

Dictyostelium 150, 156

Dictyostelium discoideum 156–1

DIF (differentiation-inducing factor) 156

dilated cardiomyopathy 208

diphenyleneiodonium chloride (DPI) 202

disulfide formation (DTT) 100

domain-centric view of apoptosis 94–96

domain concept 71–9

domain descriptors 78

domain detection methods 73–74

dronc 43

Drosophila, apoptosis in 38, 150, 183–88

caspases in 188–2

Damm 34, 41, 189, 190

Dcp-1 36, 41, 189, 190

Decay 36, 189, 190

Dredd/Dcp-2 33, 188–1

drICE 36, 41, 189, 190

Dronc/Nc 33, 34, 36, 41, 188, 189

Strica/Dream 188, 189

genetic screens for 183–8

mitochondrial pathway 190–3

activation of 191–4

Ark 190–3

Debcl 191

PELLE protein 79, 80

Rpr, Hid, Grim and SkI 41

in initiation of 185–80

regulation of 192–6

role in development 194–8

STRICA 34, 41

TUBE protein 79, 80

308 GENETICS OF APOPTOSIS