Drosophila melanogaster
BH protein homolog 49
caspases in 32
dark mutants 46
dcp-1 mutant 44
dredd mutant 44
E74 43
E75 43
E93 43
ecdysone 42–1
EDA (ectodysplasin A) ligand 75
EDAR 77
effector caspases 33
EGL-1 41–42
eIF4GI 204
endonuclease G 138
endoplasmic reticulum in apoptosis 96–119
apoptosis 97–104, 105
Bcl-2 family members regulation of ca2+
homeostatis 111–8
Ca2+ release 105–2
Ca2+ signaling between mitochondria
and 107–3
Ca2+ signals, regulation of mitochondrial
apoptosis 105–8
coordination of Cyt-c release by ER-
derived Ca2+ waves 110–6
mitochondrial permeability transition
regulation by by EF Ca2+ spikes 108–5,
112
signal transduction pathways 99–6
unfolded protein response (UPR) 97–5
etopside 7, 109, 206
evolution of cell-death principles 231–2
executor caspases 88
exon shuffling 71
extrinsic pathway xviii, 6
FADD (Fas-associated DD protein;mediator
of receptor-induced toxicity, MORT1) 4,
6, 15, 78, 80, 81, 94, 207
dominant-negative mutation (FADD-
DN) 4
Fas (CD95, Apo-1)2, 221, 221
FasL 1, 8, 25–5, 29, 221, 221
FLICE-inhibitory proteins see c-FLIP
functional domains in apoptosis 74GADD153 100
gelsolin 44
gene therapy 228–19
generalized profile (GP) 73
Geodia cydonium 155
gld mutation 24
glioblastoma 228
granzyme A 217, 219
granzyme B 23, 217, 219Hacl 97
Haclp 97
g-herpesviruses 81
hexokinase 121
hid 43
hidden Markov model methods (HMM) 73
HIV infection, role of yeast in understanding
148–3
homology domains 71–9
Hrk 91
HtrA2 41
humanin 206
huntingtin 206
Huntington’s disease 202
Hydra, apoptosis in 150, 151–7, 155
during gamete development 153–8
during spermatogenesis 154
Hydractinia, apoptosis in 150, 154, 155IAP family 7, 16, 216
ICAD 44
IFI-domain 84–2
IkB kinase (IKK) 14, 15
IKKa 14
IKKb 14, 15, 19
IKK1 (NEMO, IKKAP1) 14
inhibitor-of-apoptosis (IAPs) 12–14, 138
initiator caspases 33, 88
instructive apoptosis 1
intermembrane space (IMS) 96
internucleosomal DNA fragmentation 3
INTERPRO 74
intrinsic pathway xviii, 6
IRAK kinases 80
Irel 117INDEX 309