Genetics of Apoptosis

Irela 99
Ire1b 99
Ire1p 99
irinotecan 7

JNK 8, 15, 16, 18, 102–9
JNK/AP1 15

LARD 1, 6
L-Dnase II 221
Leishmania 158, 159
leukocyte elastase inhibitor (LEI) 221
lipocalins 201–2
lymphotoxin a 1, 75

mda-7 209
Mediterranean periodic fever syndrome 84
metacaspases 88–5
mitochondria 119–33
activation of the multidomain Bcl-2
proteins 128–3
activities of the proteins released 137–1
apoptosis pathways 6, 124
receptor pathway 123, 124
apoptosis regulation by ER Ca2+ signals
105–8
Bax and mitochondrial respiration 138–2
Bcl-2 protein family 124–20
BH3-domain-only proteins as
multidomain protein activators 130
channel-forming activity 126–2
control of caspase-independent
programmed cell death 221–16, 223
role of B-cl-2 proteins in releasing
proteins 130–30
Bax-ANT channels 137
Bax channels 131–8, 136
Bax-VDAC channels 134–30
release mechanisms 131
structure 119–16, 126–2
mitochondrial apoptosis-induced channel
(MAC) 55, 132
mitochondrial membrane permeabilization
(MMP) 221–14, 225
mitochondrial pathway 6, 124
mitochondrial permeability potential 121
MKK4 (SEK1) 8

molluscum contagiosum virus (MCV) 81

MORT1 see FADD

MRIT 11, 18, 81

Muckle-Wells syndrome 84

MyD88 80, 87, 94

NACHT domain 94

NACHT NTPase domains 93–9

NAIP 12, 41

NALP1 84

NB-ARC domain (AP-ARPase domain) 93–9

NDF 207, 209

necrosis-like programmed cell death 213–5

nervous system, alternative cell death in 230–

21

NFAT 67

NF-kB 11, 14–18

inactivation by caspase-mediated

proteolysis 19

role in protection from death-receptor-

induced apoptosis 15–16

regulation of death receptor-induced

apoptosis 16–18

death domains in activation pathway 80

NF-kB-inducing kinase (NIK) 15

NGF-R 78

NIP3 207

Nod1/CARD4 84

noncaspase proteases as mediators of

programmed cell death 217–11, 219

Noxa 26

NSP-C 115

nuclear shrinkage 3

oligomycin 138, 139

Omi/htra 2 225

origin of apoptosis 146–1

osteoprotegerin (OPG) 75, 77

OX-40L 75

p52 15

p53 26

p53 tumor suppressor gene 26, 29

p75NGFR 75

paclitaxel 65, 130

PAK2 44

Panagrellus revidus 182

310 GENETICS OF APOPTOSIS