Advances in Medicine and Biology. Volume 107

Table 1. Anti-coxsackievirus B 3 activity of S. arenaria extracts in Vero cells

Extracts CC 50 (μg/mL) IC 50 (μg/mL) SI

Roots

Crude extract 4000 b ± 0. 19 nd nd

EtOAc fraction 4000 b± 0. 09 722.22d ± 0.15 5.53

n-BuOH fraction 2000 a ± 0. 3 Nd nd

Water fraction 2000 a ± 0. 23 938.59f ± 0.1 2. 13

Flowers

Crude extract 4000 b ± 0. 31 Nd nd

EtOAc fraction 4000 b ± 0. 05 Nd nd

n-BuOH fraction 2000 a ± 0. 03 750 e ± 0.12 2. 66

Water fraction 2000 a ± 0. 07 Nd nd

Fruits

Crude extract 4000 b ± 0. 08 nd nd

EtOAc fraction 4000 b± 0. 09 nd nd

n-BuOH fraction 2000 a ± 0. 43 nd nd

Water fraction 500 a ± 0. 13 nd nd

(Stems and leaves)

Crude extract 4000 b ± 0. 24 nd nd

EtOAc fraction 4000 b ± 0. 21 nd nd

n-BuOH fraction 1000 a ± 0. 09 nd nd

Water fraction 500 a ± 0. 05 nd nd

Subfractions

SR1 4000 b ± 0. 05 620 b ± 0.0 5 6.45

SR2 4000 b ± 0. 07 1750 g ± 0.02 2.28

SR3 4000 b ± 0. 07 1876 h ± 0.1 2.13

SR4 4000 b ± 0. 2 697.34b ± 0.04 5.73

Ribavirin (positive control) 1576 a (6453.6 μM) ± 0.09 224 a (917.26 μM) ± 0.02 7.03 (^)
CC 50 : 50% cytotoxic concentration; IC 50 : 50% inhibitory concentrations; Selectivity index (SI = CC 50 /IC 50 ); nd: not determined, the
different letters (a–h) indicate a significant difference between the extracts (P < 0.05)