Self and Memory 233“9x6” b2726 Self and the Phenomenon of Life: A Biologist Examines Life from Molecules to Humanity- Si K, Lindquist S, Kandel ER.(2003) A neuronal isoform of the Aplysia
CPEB has prion-like properties. Cell 115: 879–891. - It has been reported that humans carrying a certain genotype of prion are
associated with better long-term memory. See: Papassotiropoulos A, Woll-
mer MA, Aguzzi A, et al. (2005) The prion gene is associated with human
long-term memory. Human Molec Genetics 14: 2241–2246. - Quinn WG, Harris WA, Benzer S. (1974) Conditioned behavior in
Drosophila melanogaster. Proc Natl Acad Sci USA 71:708–712. - Chen C-C, Wu J-K, Lin H-W, et al. (2012) Visualizing long-term memory
formation in two neurons of the Drosophila brain. Science 335: 678–685. - Ardiel EL, Rankin CH. (2010) An elegant mind: Learning and memory in
Caenorhabditis elegans. Learning Memory. 17: 191–201. - Bliss T, Lømo T. (1973) Long-lasting potentiation of synaptic transmission
in the dentate area of the anaesthetized rabbit following stimulation of the
perforant path. J Physiol 232: 331–356. - The events in the post-synaptic dendritic spine involve the NMDA type
of glutamate receptor and the activation of signal transducers PKA and
MAPK. These transducers enter the cell nucleus and activate the tran-
scription factor CREB, which in turn leads to gene expression making
possible synthesis of new proteins to be used for the dendritic spine.
Note that the mechanism of post-synaptic gene activation is in many
ways similar to the pre-synaptic counterpart depicted in Fig. 10.6. See:
Impey S, Obrietan K, Wong ST, et al. (1998) Cross talk between ERK
and PKA is required for Ca2+ stimulation of CREB-dependent tran-
scription and ERK nuclear translocation. Neuron 21: 869–883; Barco
A, Alarcon JM, Kandel ER. (2002) Expression of constitutively active
CREB protein facilitates the late phase of long-term potentiation by
enhancing synaptic capture. Cell 108 : 689–703; Pittenger C, Huang
YY, Paletzki RF, et al. (2002) Reversible inhibition of CREB/ATF tran-
scription factors in region CA1 of the dorsal hippocampus disrupts
hippocampus-dependent spatial memory. Neuron 34: 447–462; Zhai S,
Ark ED, Parra-Bueno P, Yasuda R. (2013) Long-distance integration of
nuclear ERK signaling triggered by activation of a few dendritic spines.
Science 342: 1107–1111. - The mechanism of long-term depression (LTD) goes like this. Low
frequency stimulation of the NMDA receptor leads to a partial relief of