Self And The Phenomenon Of Life: A Biologist Examines Life From Molecules To Humanity

(Sean Pound) #1

234 Self and the Phenomenon of Life


b2726 Self and the Phenomenon of Life: A Biologist Examines Life from Molecules to Humanity “9x6”

magnesium blockade of the receptor, but the small calcium influx is insuf-
ficient to activate CaMKII. Instead, the small, sustained calcium flow acti-
vates protein phosphatase 1 (PP1), which, through removal of phosphates,
leads to the internalization of AMPA receptor, weakening the synaptic
strength. The outcome is the impairment of synaptic transmission, the
opposite of LTP.


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