Self and the Beginning of Life 71
“9x6” b2726 Self and the Phenomenon of Life: A Biologist Examines Life from Molecules to Humanity
Wei K, et al. (2000) Ribozyme-catalyzed tRNA aminoacylation. Nature Struc-
tural Biol 7: 28–33; Johnston WK, Unrau PJ, Lawrence MS, et al. (2001)
RNA-catalyzed RNA polymerization: Accurate and general RNA-templated
primer extension. Science 292: 1319–1325; Joyce GF. (2002) The antiquity of
RNA-based evolution. Nature 418: 214–221; Lincoln TA, Joyce GF. (2009)
Self-sustained replication of an RNA enzyme. Science 323: 1229–1232; Ferretti
AC, Joyce GF. (2013) Kinetic properties of an RNA enzyme that undergoes
self-sustained exponential amplification. Biochemistry 52: 1227–1235.
- Ferris JP. (2006) Montmorillonite-catalysed formation of RNA oligomers:
The possible role of catalysis in the origins of life. Philos Trans R Soc Lond
B361: 1777–1786.
- Costanzo G, Pino S, Ciciriello F, Di Mauro E. (2009) Generation of long
RNA chains in water. J Biol Chem 284: 33206–33216.
- Meinert C, Myrgorodska I, de Marcellus P, et al. (2016) Ribose and related
sugars from ultraviolet irradiation of interstellar ice analogs. Science 352:
208–212.
- Ricardo A, Carrigan MA, Olcott AN, Benner SA. (2004) Borate minerals
stabilize ribose. Science 303: 196.
- Shapiro R. (1999) Prebiotic cytosine synthesis: A critical analysis and impli-
cations for the origin of life. Proc Natl Acad Sci USA 96: 4396–4401.
- Fuller WD, Sanchez RA, Orgel LE. (1972) Studies in prebiotic synth-
esis VI. Synthesis of purine nucleosides. J Mol Biol 67: 25–33; Fuller WD,
Sanchez RA, Orgel LE. (1972) Studies in prebiotic synthesis. VII Solid-
state synthesis of purine nucleosides. J Mol Evol 1: 249–257; Orgel LE.
(2004) Prebiotic chemistry and the origin of the RNA world. Crit Rev Bio
chem Mol Biol 39: 99–123.
- Sutherland’s method synthesized cytosine ribonucleotide by the following
steps. Cyanamide was reacted with glycolaldehyde to obtain 2-amino-oxazole.
The latter was added to glyceraldehyde to yield the pentose amino-oxazolines
including the arabinose derivative. The arabinose amino-oxazoline was then
reacted with cyanoacetylene to give the anhydroarabinonucleoside, which
was then phosphorylated to yield ß-ribocytidine-2′,3′-cyclic phosphate, an
activated ribonucleotide needed for RNA synthesis. The corresponding ura-
cil nucleotide was subsequently converted from the cytosine nucleotide by
ultraviolet irradiation. See: Powner MW, Gerland B, Sutherland JD. (2009)