Endophytic Fungi Are Multifunctional Biosynthesizers 65Figure 5. Chemical structures (31-34) show the diversity of glycosides compounds
isolated from endophytic fungi.
10.4. Peptides
Xylaria sp. as a seed-endophye of an angiosperm tree found in the South
China Sea produced a new cyclic peptide (35) with an unusual allenic ether
linkage of an N-(p-hydroxycinnamoyl) amide. The molecular formula of the
compound was determined by combining the data obtained from elemental
analysis. The allenic ether linkage identified by IR (Lin et al., 2001).
Epichlicin (36), a new cyclic peptide, was isolated from the endophytic fungus
Epichloe typhina derived from Phleum pratense L. Through the combination
between advanced Marfey method and chemical investigation the
stereochemical configuration of its atoms was identified (Seto et al., 2007).
Advanced Marfey’s method that involve acid hydrolysis (Fujii et al.,
1997) is used widely to assign the absolute configuration of peptides. This
method was used for the determination of the absolute configuration of
pullularins E (37) and F (38), two novel cyclic peptides identified from the
extracts of the fungus Bionectriaochroleuca isolated from the leaves of the
Sonneratia caseolaris (Ebrahim et al., 2012). Another example of using
advanced Marfey’s for peptides is the isolation and structure elucidation of
two new cyclic peptides, namely talaromins A (39) and B (40). Their ring