Human Physiology, 14th edition (2016)

(Tina Sui) #1
Enzymes and Energy 105


  1. What two pH values produce half-maximal activity of
    salivary amylase?

  2. What two pH values produce half-maximal activity of
    pepsin?

  3. At what pH is the activity of pepsin and salivary amylase
    equal?

  4. Gastric juice normally has a pH of 2. Given this, what
    happens to the activity of salivary amylase, a starch-
    digesting enzyme in saliva, when it arrives in the stomach?


24
pH

Enzyme activity

6810

Pepsin Salivary
amylase

Trypsin


  1. A student, learning that someone has an elevated blood level
    of lactate dehydrogenase (LDH), wonders how the enzyme
    got into this person’s blood and worries about whether it will
    digest the blood. What explanation can you give to allay the
    student’s fears?

  2. Suppose you come across a bottle of enzyme tablets at your
    local health food store. The clerk tells you this enzyme
    will help your digestion, but you notice that it is derived
    from a plant. What concerns might you have regarding the
    effectiveness of these tablets?

  3. Describe the energy transformations that occur when sunlight
    falls on a field of grass, the grass is eaten by a herbivore (such
    as a deer), and the herbivore is eaten by a carnivore (such as
    a cougar). Use the laws of thermodynamics to explain why
    there is more grass than deer, and more deer than cougars (in
    terms of their total biomass).

  4. Use the reversible reactions involving the formation and
    breakdown of carbonic acid, and the law of mass action,
    to explain what would happen to the blood pH of a
    person who is hypoventilating (breathing inadequately) or
    hyperventilating (breathing excessively).


Test Your Quantitative Ability


Use the graph here and in figure 4.4 to answer the following
questions:



  1. What are the pH optima of these three enzymes?


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