Human Physiology, 14th edition (2016)

(Tina Sui) #1
Reproduction 753


  1. Which of the following statements regarding
    spermatogenesis is false?
    a. Testosterone stimulates spermatogenesis.
    b. The chromatin becomes highly compacted as protamines
    replace histone proteins.
    c. Sertoli cells engulf spermatid cytoplasm by phagocytosis.
    d. FSH is required for spermatogenesis to occur.

  2. Which of the following statements about progesterone is false?


a. Progesterone is secreted by the corpus luteum
b. Progesterone is secreted by the placenta.
c. Progesterone decreases the basal body temperature.
d. Progesterone secretion drops towards the end of the
nonfertile luteal phase.

Test Your Understanding



  1. Identify the conversion products of testosterone and describe
    their functions in the brain, prostate, and seminiferous tubules.

  2. Explain why a testis is said to be composed of two separate
    compartments. Describe the interactions that may occur
    between these compartments.

  3. Describe the roles of the Sertoli cells in the testes.

  4. Describe the steps of spermatogenesis and explain its
    hormonal control.

  5. Explain the hormonal interactions that control ovulation and
    cause it to occur at the proper time.

  6. Compare menstrual bleeding and bleeding that occurs during
    the estrous cycle of a dog in terms of hormonal control
    mechanisms and the ovarian cycle.

  7. “The [contraceptive] pill tricks the brain into thinking you’re
    pregnant.” Interpret this popularized explanation in terms of
    physiological mechanisms.

  8. Why does menstruation normally occur? Under what
    conditions does menstruation not occur? Explain.

  9. Explain the proposed mechanisms whereby the act of
    a mother nursing her baby results in lactation. By what
    mechanisms might the sound of a baby crying elicit the
    milk-ejection reflex?

  10. Describe the steps of oogenesis when fertilization occurs and
    when it does not occur. Why are polar bodies produced?

  11. Identify the hormones secreted by the placenta. Why is the
    placenta considered an incomplete endocrine gland?

  12. Describe the endocrine changes that occur at menopause and
    discuss the consequences of these changes. What are the benefits
    and risks associated with hormone replacement therapy?

  13. Explain the sequence of events by which the male
    accessory sex organs and external genitalia are produced.


What occurs when a male embryo lacks receptor proteins
for testosterone? What occurs when a male embryo lacks the
enzyme 5 a -reductase?


  1. Describe the mechanisms that have been proposed to time
    the onset of parturition in sheep and humans.


Test Your Analytical Ability


  1. According to your friend, there is a female birth control pill
    and not a male birth control pill only because the medical
    establishment is run by men. Do you agree with her conspiracy
    theory? Provide physiological support for your answer.

  2. Elderly men with benign prostatic hyperplasia are
    sometimes given estrogen treatments. How would this help
    the condition? What other types of drugs may be given, and
    what would you predict their possible side effects to be?

  3. Discuss the role of apoptosis and follicle atresia in ovarian
    physiology. How might this process be regulated?

  4. Is it true that estrogen is an exclusively female hormone and
    that testosterone is an exclusively male hormone? Explain
    your answer.

  5. Surgical removal of a woman’s ovaries (ovariectomy) can
    precipitate menstruation. Ovariectomy in a dog or cat,
    however, does not cause the discharge of uterine blood. How
    can you explain these different responses?

  6. Endometrial tissue is maintained by estrogen, and yet
    endometriosis is treated with a GnRH agonist drug. Explain
    this seeming paradox.

  7. If scientists developed a new drug to block the FSH receptor
    in men, or to reduce a man’s FSH secretion, would that
    lead to a male contraceptive pill? Explain, in terms of the
    hormonal control of spermatogenesis.

  8. Describe the locations and characteristics of adult stem
    cells. How does their potential relate to normal embryonic
    tissue development? What are the potential advantages and
    disadvantages of using adult stem cells, compared to embryonic
    stem cells, for regenerative medicine (stem cell therapies)?


Test Your Quantitative Ability
Refer to figure 20.32 to answer the following questions:


  1. During which range of days are the secretions of both
    estradiol and progesterone at their highest levels in the graph?

  2. What is the percentage increase in LH secretion in the day
    leading up to the LH peak?

  3. In the 5 days leading up to the LH peak, what is the
    percentage increase in estradiol secretion?

  4. At 5 days after the LH peak, how many times greater is the
    blood concentration of progesterone compared to estradiol?
    (Hint: a picogram is 10^2 12  g, whereas a nanogram is 10^2 9  g.)


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