7 Evidence Appraisal: Nonresearch 147
instrument with documented reliability and validity, found that the availability
of background information was the strongest predictor of guideline quality and
that high-quality guidelines were more often produced by government-supported
organizations or a structured, coordinated program (Fervers et al., 2005). The
AGREE instrument, revised in 2013, now has 23 items and is organized into six
domains (The AGREE Research Trust, 2013; Brouwers et al., 2010):
- Scope and purpose
- Stakeholder involvement
- Rigor of development
- Clarity of presentation
- Applicability
- Editorial independence
The National Guideline Clearinghouse (NGC), an initiative of the Agency for
Healthcare Research and Quality (AHRQ), U.S. Department of Health and Hu-
man Services, is another excellent source of high-quality guidelines and is known
for its rigorous standards. The NGC recently revised the criteria designed to en-
sure rigor in developing and maintaining published guidelines (NGC, 2013). The
revised criteria stipulate that the guidelines:
■■ Contain systematically developed statements, including recommendations
to optimize patient care and assist physicians and/or other healthcare
practitioners and patients to make decisions
■■ Have been produced by a medical specialty association, relevant profes-
sional society, public or private organization, government agency, or
healthcare organization or plan
■■ Be based on a systematic review of evidence
■■ Contain an assessment of the benefits and harms of recommended care
and alternative care options