AMPK Methods and Protocols

(Rick Simeone) #1
kinase activation. Expert Opin Investig Drugs
21:1155–1167


  1. Bess E, Fisslthaler B, Fromel T, Fleming I
    (2011) Nitric oxide-induced activation of the
    AMP-activated protein kinase alpha2 subunit
    attenuates IkappaB kinase activity and inflam-
    matory responses in endothelial cells. PLoS
    One 6:e20848

  2. Rutherford C, Speirs C, Williams JJ et al
    (2016) Phosphorylation of Janus kinase
    1 (JAK1) by AMP-activated protein kinase
    (AMPK) links energy sensing to anti-
    inflammatory signaling. Sci Signal 9:ra109

  3. Zhang Y, Qiu J, Wang X, Xia M (2011)
    AMP-activated protein kinase suppresses endo-
    thelial cell inflammation through phosphoryla-
    tion of transcriptional coactivator p300.
    Arterioscler Thromb Vasc Biol 31:2897–2908

  4. Schulz E, Dopheide J, Schuhmacher S et al
    (2008) Suppression of the JNK pathway by
    induction of a metabolic stress response pre-
    vents vascular injury and dysfunction. Circula-
    tion 118:1347–1357

  5. Mancini SJ, White AD, Bijland S et al (2017)
    Activation of AMP-activated protein kinase
    rapidly suppresses multiple pro-inflammatory
    pathways in adipocytes including IL-1 recep-
    tor-associated kinase-4 phosphorylation. Mol
    Cell Endocrinol 440:44–56

  6. He C, Li H, Viollet B et al (2015) AMPK
    suppresses vascular inflammation in vivo by
    inhibiting Signal Transducer and Activator of
    Transcription-1. Diabetes 64:4285–4297

  7. Guma M, Firestein GS (2012) C-Jun N-termi-
    nal kinase in inflammation and rheumatic dis-
    eases. Open Rheumatol J 6:220–231

  8. Pal M, Febbraio MA, Lancaster GI (2016) The
    roles of c-Jun NH2-terminal kinases (JNKs) in
    obesity and insulin resistance. J Physiol
    594:267–279

  9. Zehorai E, Seger R (2014) Beta-like Importins
    mediate the nuclear translocation of mitogen-
    activated protein kinases. Mol Cell Biol
    34:259–270

  10. Griffith JW, Sokol CL, Luster AD (2014) Che-
    mokines and chemokine receptors: positioning
    cells for host defense and immunity. Annu Rev
    Immunol 32:659–702

  11. Newton K, Dixit VM (2012) Signaling in
    innate immunity and inflammation. Cold
    Spring Harb Perspect Biol 4(3). pii: a006049

  12. Gerhardt T, Ley K (2015) Monocyte traffick-
    ing across the vessel wall. Cardiovasc Res
    107:321–330

  13. Tabas I, Bornfeldt KE (2016) Macrophage
    phenotype and function in different stages of
    atherosclerosis. Circ Res 118:653–667

  14. Bultot L, Jensen TE, Lai YC et al (2016) Benz-
    imidazole derivative small-molecule
    991 enhances AMPK activity and glucose
    uptake induced by AICAR or contraction in
    skeletal muscle. Am J Physiol Endocrinol
    Metab 311:E706–E719

  15. Laderoute KR, Amin K, Calaoagan JM et al
    (2006) 5^0 -AMP-activated protein kinase
    (AMPK) is induced by low oxygen and glucose
    deprivation conditions found in solid-tumor
    microenvironments. Mol Cell Biol
    26:5336–5347

  16. Ross SA, Song X, Burney MW et al (2003)
    Efficient adenovirus transduction of 3T3-L1
    adipocytes stably expressing coxsackie-
    adenovirus receptor. Biochem Biophys Res
    Commun 302:354–358

  17. Woods A, Azzout-Marniche D, Foretz M et al
    (2000) Characterization of the role of
    AMP-activated protein kinase in the regulation
    of glucose-activated gene expression using con-
    stitutively active and dominant negative forms
    of the kinase. Mol Cell Biol 20:6704–6711


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