- Chapel A, Kieffer-Jaquinod S, Sagne C,
Verdon Q, Ivaldi C, Mellal M, Thirion J,
Jadot M, Bruley C, Garin J, Gasnier B, Journet
A (2013) An extended proteome map of the
lysosomal membrane reveals novel potential
transporters. Mol Cell Proteomics 12
(6):1572–1588. https://doi.org/10.1074/
mcp.M112.021980
- Nada S, Hondo A, Kasai A, Koike M, Saito K,
Uchiyama Y, Okada M (2009) The novel lipid
raft adaptor p18 controls endosome dynamics
by anchoring the MEK-ERK pathway to late
endosomes. EMBO J 28(5):477–489.https://
doi.org/10.1038/emboj.2008.308
- Sancak Y, Bar-Peled L, Zoncu R, Markhard AL,
Nada S, Sabatini DM (2010) Ragulator-Rag
complex targets mTORC1 to the lysosomal
surface and is necessary for its activation by
amino acids. Cell 141(2):290–303.https://
doi.org/10.1016/j.cell.2010.02.024
- Bar-Peled L, Schweitzer LD, Zoncu R, Sabatini
DM (2012) Ragulator is a GEF for the rag
GTPases that signal amino acid levels to
mTORC1. Cell 150(6):1196–1208.https://
doi.org/10.1016/j.cell.2012.07.032
- Kawabuchi M, Satomi Y, Takao T,
Shimonishi Y, Nada S, Nagai K,
Tarakhovsky A, Okada M (2000) Transmem-
brane phosphoprotein Cbp regulates the activ-
ities of Src-family tyrosine kinases. Nature 404
(6781):999–1003.https://doi.org/10.1038/
35010121
- Steinberg BE, Huynh KK, Brodovitch A,
Jabs S, Stauber T, Jentsch TJ, Grinstein S
(2010) A cation counterflux supports lyso-
somal acidification. J Cell Biol 189
(7):1171–1186. https://doi.org/10.1083/
jcb.200911083
- Zoncu R, Bar-Peled L, Efeyan A, Wang S,
Sancak Y, Sabatini DM (2011) mTORC1
senses lysosomal amino acids through an
inside-out mechanism that requires the vacuo-
lar H(þ)-ATPase. Science 334
(6056):678–683. https://doi.org/10.1126/
science.1207056
- Kahn BB, Alquier T, Carling D, Hardie DG
(2005) AMP-activated protein kinase: ancient
energy gauge provides clues to modern under-
standing of metabolism. Cell Metab 1
(1):15–25. https://doi.org/10.1016/j.cmet.
2004.12.003
- Steinberg GR, Kemp BE (2009) AMPK in
health and disease. Physiol Rev 89
(3):1025–1078. https://doi.org/10.1152/
physrev.00011.2008
- Carling D, Mayer FV, Sanders MJ, Gamblin SJ
(2011) AMP-activated protein kinase: nature’s
energy sensor. Nat Chem Biol 7(8):512–518.
https://doi.org/10.1038/nchembio.610
- Zhao J, Hu C, Zeng J, Zhao Y, Zhang J,
Chang Y, Li L, Zhao C, Lu X, Xu G (2014)
Study of polar metabolites in tobacco from
different geographical origins by using capillary
electrophoresis–mass spectrometry. Metabolo-
mics 10(5):805–815. https://doi.org/10.
1007/s11306-014-0631-4
- Zhao Y, Zhao J, Zhao C, Zhou H, Li Y,
Zhang J, Li L, Hu C, Li W, Peng X, Lu X,
Lin F, Xu G (2015) A metabolomics study
delineating geographical location-associated
primary metabolic changes in the leaves of
growing tobacco plants by GC-MS and
CE-MS. Sci Rep 5:16346.https://doi.org/
10.1038/srep16346
- Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou
HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin
SC (2004) Axin stimulates p53 functions by
activation of HIPK2 kinase through multi-
meric complex formation. EMBO J 23
(23):4583–4594. https://doi.org/10.1038/
sj.emboj.7600475
- Rousset CI, Leiper FC, Kichev A, Gressens P,
Carling D, Hagberg H, Thornton C (2015) A
dual role for AMP-activated protein kinase
(AMPK) during neonatal hypoxic-ischaemic
brain injury in mice. J Neurochem 133
(2):242–252. https://doi.org/10.1111/jnc.
13034
- McCullough LD, Tarabishy S, Liu L,
Benashski S, Xu Y, Ribar T, Means A, Li J
(2013) Inhibition of calcium/calmodulin-
dependent protein kinase kinase beta and
calcium/calmodulin-dependent protein kinase
IV is detrimental in cerebral ischemia. Stroke
44(9):2559–2566.https://doi.org/10.1161/
STROKEAHA.113.001030
- Faupel RP, Seitz HJ, Tarnowski W,
Thiemann V, Weiss C (1972) The problem of
tissue sampling from experimental animals with
respect to freezing technique, anoxia, stress
and narcosis. A new method for sampling rat
liver tissue and the physiological values of gly-
colytic intermediates and related compounds.
Arch Biochem Biophys 148(2):509–522
Analysis of Lysosomal AMPK Activation 411