References
- Feil R, Fraga MF (2012) Epigenetics and the
environment: emerging patterns and implica-
tions. Nat Rev Genet 13:97.https://doi.org/
10.1038/nrg3142. nrg3142 [pii] - Heard E, Martienssen RA (2014) Transgenera-
tional epigenetic inheritance: myths and
mechanisms. Cell 157(1):95–109. https://
doi.org/10.1016/j.cell.2014.02.045 - Gapp K, von Ziegler L, Tweedie-Cullen RY,
Mansuy IM (2014) Early life epigenetic pro-
gramming and transmission of stress-induced
traits in mammals: How and when can environ-
mental factors influence traits and their trans-
generational inheritance? Bioessays 36
(5):491–502.https://doi.org/10.1002/bies.
201300116 - Grossniklaus U, Kelly WG, Kelly B, Ferguson-
Smith AC, Pembrey M, Lindquist S (2013)
Transgenerational epigenetic inheritance: how
important is it? Nat Rev Genet 14(3):228–235.
https://doi.org/10.1038/nrg3435 - Ahmed F (2010) Epigenetics: Tales of adver-
sity. Nature 468(7327):S20.https://doi.org/
10.1038/468S20a. 468S20a [pii] - Heijmans BT, Tobi EW, Stein AD, Putter H,
Blauw GJ, Susser ES, Slagboom PE, Lumey
LH (2008) Persistent epigenetic differences
associated with prenatal exposure to famine in
humans. Proc Natl Acad Sci U S A 105
(44):17046–17049. https://doi.org/pnas.
080/pnas.0806560105,0806560105[pii] - Lumey LH, Stein AD, Susser E (2011) Prena-
tal famine and adult health. Annu Rev Public
Health 32:237–262. https://doi.org/10.
1146/annurev-publhealth-031210-101230 - Tobi EW, Slagboom PE, van Dongen J,
Kremer D, Stein AD, Putter H, Heijmans BT,
Lumey LH (2012) Prenatal famine and genetic
variation are independently and additively asso-
ciated with DNA methylation at regulatory loci
within IGF2/H19. PLoS One 7(5):e37933.
https://doi.org/10.1371/journal.pone.
0037933,PONE-D-12-01997[pii] - Stein AD, Zybert PA, van de Bor M, Lumey
LH (2004) Intrauterine famine exposure and
body proportions at birth: the Dutch Hunger
Winter. Int J Epidemiol 33(4):831–836.
https://doi.org/10.1093/ije/dyh083,
dyh083[pii] - Roseboom T, de Rooij S, Painter R (2006) The
Dutch famine and its long-term consequences
for adult health. Early Hum Dev 82
(8):485–491. https://doi.org/10.1016/j.
earlhumdev.2006.07.001,S0378-3782(06)
00184-8[pii]
- Kelly WG (2014) Transgenerational epige-
netics in the germline cycle of Caenorhabditis
elegans. Epigenetics Chromatin 7(1):6.
https://doi.org/10.1186/1756-8935-7-6 - Greer EL, Beese-Sims SE, Brookes E,
Spadafora R, Zhu Y, Rothbart SB, Aristizabal-
Corrales D, Chen S, Badeaux AI, Jin Q,
Wang W, Strahl BD, Colaiacovo MP, Shi Y
(2014) A histone methylation network regu-
lates transgenerational epigenetic memory in
C. elegans. Cell Rep 7(1):113–126.https://
doi.org/10.1016/j.celrep.2014.02.044,
S2211-1247(14)00158-2[pii] - Greer EL, Maures TJ, Ucar D, Hauswirth AG,
Mancini E, Lim JP, Benayoun BA, Shi Y, Bru-
net A (2011) Transgenerational epigenetic
inheritance of longevity in Caenorhabditis ele-
gans. Nature 479:365. https://doi.org/10.
1038/nature10572. nature10572 [pii] - Lim JP, Brunet A (2013) Bridging the transge-
nerational gap with epigenetic memory. Trends
Genet 29(3):176–186. https://doi.org/10.
1016/j.tig.2012.12.008,S0168-9525(12)
00212-0[pii] - Demoinet E, Li S, Roy R (2017) AMPK blocks
starvation-inducible transgenerational defects
in Caenorhabditis elegans. Proc Natl Acad Sci
U S A 114(13):E2689–E2698.https://doi.
org/10.1073/pnas.1616171114 - Brenner S (1974) The genetics of Caenorhab-
ditis elegans. Genetics 77(1):71–94 - Goodyer W, Kaitna S, Couteau F, Ward JD,
Boulton SJ, Zetka M (2008) HTP-3 links
DSB formation with homolog pairing and
crossing over during C. elegans meiosis. Dev
Cell 14(2):263–274. https://doi.org/10.
1016/j.devcel.2007.11.016,S1534-5807(07)
00438-8[pii] - Artyukhin AB, Schroeder FC, Avery L (2013)
Density dependence in Caenorhabditis larval
starvation. Sci Rep 3:2777.https://doi.org/
10.1038/srep02777,srep02777[pii] - Mok DZ, Sternberg PW, Inoue T (2015) Mor-
phologically defined sub-stages of C. elegans
vulval development in the fourth larval stage.
BMC Dev Biol 15:26.https://doi.org/10.
1186/s12861-015-0076-7
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