73References
- Aldridge BB, Keren I, Fortune SM (2014)
The spectrum of drug susceptibility in myco-
bacteria. Microbiol Spectr 2:1–14. https://
doi.org/10.1128/microbiolspec.MGM2-
0031-2013 - Bacon J, James BW, Wernisch L et al (2004)
The influence of reduced oxygen availability on
pathogenicity and gene expression in
Mycobacterium tuberculosis. Tuberculosis
(Edinb) 84:205–217. https://doi.org/
10.1016/j.tube.2003.12.011 - Bacon J, Dover LG, KA H et al (2007) Lipid
composition and transcriptional response of
Mycobacterium tuberculosis grown under iron-
limitation in continuous culture: identification
of a novel wax ester. Microbiology 153:1435–
1444. https://doi.org/10.1099/mic.0.2006/
004317-0 - Golby P, Hatch KA, Bacon J et al (2007)
Comparative transcriptomics reveals key gene
expression differences between the human and
bovine pathogens of the Mycobacterium tuber-
culosis complex. Microbiology 153:3323–3336.
https://doi.org/10.1099/mic.0.2007/
009894-0
5. Beste DJV, Espasa M, Bonde B et al (2009) The
genetic requirements for fast and slow growth in
mycobacteria. PLoS One 4:e5349. https://doi.
org/10.1371/journal.pone.0005349
6. Jeeves RE, Marriott AA, Pullan ST et al (2015)
Mycobacterium tuberculosis is resistant to iso-
niazid at a slow growth rate by single nucleotide
polymorphisms in katG codon Ser315. PLoS
One 10:e0138253. https://doi.org/10.1371/
journal.pone.0138253
7. Pullan ST, Allnutt JC, Devine R et al (2016)
The effect of growth rate on pyrazinamide
activity in Mycobacterium tuberculosis –
insights for early bactericidal activity? BMC
Infect Dis 16:205. https://doi.org/10.1186/
s12879-016-1533-z
8. Jenkins C, Bacon J, Allnutt J et al (2009)
Enhanced heterogeneity of rpoB in
Mycobacterium tuberculosis found at low pH. J
Antimicrob Chemother 63:1118–1120.
https://doi.org/10.1093/jac/dkp1259.
9. Beste DJ, Hooper T, Stewart G et al (2007)
GSMN-TB: a web-based genome-scale net-
work model of Mycobacterium tuberculosis
metabolism. Genome Biol 8:R89. https://doi.
org/10.1186/gb-2007-8-5-r89
Application of Continuous Culture for Assessing Antibiotic Activity Against...