173
Pesticide
Allethrin, d‐trans Estrogen Unknown
Amitrol Thyroid Thyroid peroxidase
inhibitors; inhibits thyroid
hormone synthesis.
Atrazine Neuroendocrine‐
pituitary (depression of
LH surge), testosterone
metabolism
Inhibits ligand binding to
androgen and estrogen
receptors
Carbaryl Estrogen and
progesterone
Unknown
Chlofentezine Thyroid Enhances secretion of thyroid
hormone
Chlordane Testosterone and
progesterone
Unknown
Cypermethrin Disruption of
reproductive function
Unknown
DDT Estrogen DDT and related compounds
act in a number of ways to
disrupt endocrine function by
binding with the estrogen
receptor, including estrogen
mimickry and antagonism,
altering the pattern of
synthesis or metabolism of
hormones, and modifying
hormone receptor levels
DDT metabolite,
p,p′‐DDE
Androgen Inhibits androgen binding to
the androgen receptor,
androgen‐induced
transcriptional activity, and
androgen action in
developing, pubertal and
adult male rats
Dicofol (Kelthane) Estrogen Unknown
Dieldrin Estrogen Binds to estrogen receptor;
competes with estradiol
Endosulfan Estrogen Unknown
Ethylene thiourea Thyroid Thyroid peroxidase inhibitor
Fenarimol Estrogen Estrogen receptor agonist
(Continued)
Compound(s) Hormone Mechanism
Table 7.1 (Continued)
Autism and Exposure to Environmental Chemicals