Devita, Hellman, and Rosenberg's Cancer

LWBK1006-20 LWW-Govindan-Review December 12, 2011 19:4

Chapter 20•Cancer of the Gastrointestinal Tract 237

Question 20.1.18.Which of the following statements about the molecular biology of

esophageal cancer is/are TRUE?

A. EGFR overexpression correlates with poor prognosis including poor

response to chemotherapy.

B. Presence of p53 point mutation correlates with response to induction

chemotherapy and predicts survival after esophagectomy.

C. Reduced expression of E-cadherin correlates with progression from

Barrett’s esophagus to dysplasia and finally to adenocarcinoma.

D. All of above.

Question 20.1.19.Which of the following statements is/are correct regarding gastric cancer?

A. Prophylactic gastrectomy should be considered strongly in families

with germ line E-cadherin mutation even without gross mucosal

abnormalities on endoscopic examination of the stomach.

B. p53 tumor suppressor gene is not involved in most gastric cancers.

C. ‘Microsatellite instability’ is one of the mechanisms involved in the

pathogenesis of sporadic gastric cancers.

D. A&C.