Devita, Hellman, and Rosenberg's Cancer

LWBK1006-20 LWW-Govindan-Review December 12, 2011 19:4

256 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 20.3.15.Which of the following statements is INCORRECT?

A. The hepatitis B x gene product has been implicated in causing HCC.

B. NS5A protein product of hepatitis C viral (HCV) genome does not

interact with p53.

C. Level of HBV replication is not inversely related to the risk of liver

cancer.

D. Hepatitis B virus genotype C is associated with increased risk of HCC.

Question 20.3.16.Which of the following statements is/are correct?

A. 60% to 80% HCV infections become chronic in contrast to 10%

HBV infections.

B. HBV genome integrates into hepatocyte DNA while HCV genome

does not.

C. The average interval from HCV infection to HCC is 30 years in con-

trast to 40 to 50 years for HBV infection.

D. All of above.

Question 20.3.17.Which of the following is NOT an independent predictor for the devel-

opment of HCC in chronic hepatitis C infection?

A. Thrombocytosis

B. Esophageal varices

C. Smoking

D. African American ethnicity

Question 20.3.18.Which of the following features are characteristic of the appearance of

HCC on four-phase CT?

A. Presence of arterial hypervascularity

B. Rapid enhancement during the arterial phase of contrast administra-

tion

C. Washout during the later portal venous and delayed phase

D. All of the above

Question 20.3.19.Which of the following individuals would not meet criteria to have surveil-

lance for HCC?

A. 28-year-old African American woman who is a hepatitis B carrier.

B. 47-year-old Indian woman who is hepatitis B carrier.

C. 62-year-old Hispanic male with alcoholic cirrhosis.

D. 42-year-old Chinese man who is a hepatitis B carrier.