LWBK1006-23 LWW-Govindan-Review December 12, 2011 19:10
CHAPTER 23 GYNECOLOGIC
CANCERS
SECTION 1 OVARIAN
DAVID G. MUTCHDIRECTIONS Each of the numbered items below is followed by lettered answers. Select the
ONE lettered answer that is BEST in each case unless instructed otherwise.QUESTIONS
Question 23.1.1. A 35-year-old premenopausal woman of Ashkenazi Jewish ancestry
presents to you because her 60-year-old paternal aunt was recently diag-
nosed with ovarian cancer, and she is concerned about her own risk for
ovarian cancer. She has no siblings, and there is no other family history of
cancer. She has two living children and is in good health, and her pelvic
examination is unremarkable. You should advise her that:
A. Ovarian cancer cannot be inherited through the paternal side, and
she does not need any particular screening.
B. A single second-degree relative with cancer at age more than 50 years
does not confer a significantly increased risk for her.
C. She should visit a genetic counselor.
D. Annual transvaginal ultrasound and CA-125 screening can reduce
her risk of mortality.
E. She should have a prophylactic total abdominal hysterectomy/
bilateral salpingo-oophorectomy (TAH/BSO) if/when she does not
want to have any more children.Corresponding Chapter inCancer: Principles & Practice of Oncology,Ninth Edition: 104 (Ovarian Cancer, Fallopian
Tube Carcinoma, and Peritoneal Carcinoma).305