Devita, Hellman, and Rosenberg's Cancer

LWBK1006-23 LWW-Govindan-Review December 12, 2011 19:10

Chapter 23•Gynecologic Cancers 315

Question 23.2.3. Genetic changes commonly seen in type I endometrial cancers include:

A. KRAS mutation

B. PTEN mutation

C. -catenin mutation

D. All of the above

Question 23.2.4. All of the following genetic changes are characteristic of type II endome-

trial cancers, EXCEPT:

A. Microsatellite instability (MSI)

B. HER2/neu amplification

C. BCL2 overexpression

D. p53 mutations

Question 23.2.5. Risk factors for endometrial cancer include all of the following, EXCEPT:

A. Increasing age

B. Black race

C. Family history of endometrial cancer

D. Prior pelvic radiotherapy

Question 23.2.6. The majority of cervical, vaginal, and vulvar cancers appear to have a

common cause and are usually caused by:

A. Increased exposure to exogenous estrogen

B. Chronic bacterial and parasitic infections

C. Multiple prior herpes simplex virus (HSV) infections

D. Human papillomavirus (HPV) infection with high-risk types

Question 23.2.7. In patients with gestational trophoblastic disease (GTD) with a complete

mole, molecular features include all of the following, EXCEPT:

A. Mutations in p53 have not been reported.

B. Most are diploid with duplication of a haploid paternal genome.

C. Predominance of maternal chromosomes is common.

D. Several genes, including CMYC, ERBB2, CFMS, and BCL2, have

been implicated in the pathogenesis of complete moles.

Question 23.2.8. A 39-year-old married woman is seeing you in the office after recently

having a cervical biopsy that demonstrated cervical cancer. She has no

prior medical problems other than anemia and one prior uncomplicated

child birth. You tell her all of the following epidemiologic factors are true,

EXCEPT:

A. During the past 80 years, death rates from cervical cancer have

decreased primarily because of the adoption of routine screening pro-

grams with PAP smears.

B. Cervical cancer is the second leading cause of cancer deaths for

women aged 20 to 39 years in the United States.

C. HSV is thought to be the causative agent for the majority of patients.

D. The incidence of cervical cancer is 30% and 100% higher in Black and

Hispanic women, respectively, compared with Whites in the United

States.