Devita, Hellman, and Rosenberg's Cancer

LWBK1006-30 LWW-Govindan-Review December 12, 2011 19:35

CHAPTER 30 LYMPHOMAS

CAMILLE N. ABBOUD

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 30.1. Which is NOT true of leukemias and lymphomas of childhood?

A. Demonstrate better outcomes than adults with leukemia and lym-

phomas.

B. Cure rates range from 60% to 90%, and more than two-thirds of

children are treated in clinical trials.

C. Young adults (<30 years) display similar clinical and molecular fea-

tures as seen in children.

D. Young adults are not eligible for enrollment in pediatric clinical trials.

Question 30.2. Which of the following is NOT a common translocation in Burkitt’s lym-

phoma?

A. t(1;14)

B. t(8;14)

C. t(2;8)

D. t(8;22)

Question 30.3. All of the following statements about childhood leukemias are true,

EXCEPT:

A. Bloom’s, ataxia telangiectasia, Shwachman-Diamond, Sotos, Noo-

nan’s syndromes, and neurofibromatosis are associated with

increased incidence of leukemia.

B. ALL relapses involve testicular and central nervous system (CNS)

extramedullary sites, requiring localized therapy and a second full

course of systemic therapy.

C. Down syndrome (trisomy 21) is associated with ALL in the neonatal

period.

D. ALL treatment protocols contain an intensive induction/consoli-

dation phase within 6 to 12 months followed by prolonged main-

tenance/continuation phases lasting 2 to 3 years.

Corresponding Chapters inCancer: Principles & Practice of Oncology,Ninth Edition: 125 (Molecular Biology of

Lymphomas), 126 (Hodgkin’s Lymphoma), 127 (Non-Hodgkin’s Lymphomas), 128 (Cutaneous Lymphomas), and

129 (Primary Central Nervous System Lymphoma).

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