Devita, Hellman, and Rosenberg's Cancer

LWBK1006-31 LWW-Govindan-Review December 12, 2011 19:43

438 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 31.4. Mutations in which pair of transcripts would be expected to cooperatively

contribute significantly to leukemia?

A. FLT3 and ABL

B. A core-binding factor and the retinoic acid receptor alpha

C. FLT3 and the retinoic acid receptor alpha

D. Tel-PDGFR and FLT3

Question 31.5. A 52-year-old man presents with AML. On day 2 of induction therapy,

he develops diffuse alveolar hemorrhage. An expected physical finding on

examination would be:

A. Diffuse ecchymosis

B. Diffuse intravascular coagulopathy

C. Swollen gums

D. Cardiac rub

Questions 31.6.

–31.7.

You have been following a 75-year-old woman in clinic with mild renal

insufficiency and progressive anemia. She presents to clinic with a 3-day

history of progressive fatigue and new headaches. Her white blood cell

(WBC) count is 53,000 with 50% blasts.

Question 31.6. Given her history, you might expect to find what on her cytogenetics?

A. t(15;17)

B. –7

C. inv(16)

D. t(8;21)

Question 31.7. Which of these improves her prognosis?

A. Probable leukostasis

B. Her age

C. Prior myelodysplastic syndrome (MDS)

D. Good performance status

Question 31.8. You are caring for a 70-year-old man with newly diagnosed AML. Accord-

ing to his cytogenetics, you give him an unfavorable prognosis based on

which result:

A. –7

B. t(15;17)

C. inv(16)

D. t(8;21)

Question 31.9. All of the following are considered to be poor prognosis factors in adult

ALL, EXCEPT:

A. Age>55 years

B. Leukocytosis

C. Diploid chromosomes on karyotyping

D. t(4;11)