Devita, Hellman, and Rosenberg's Cancer

LWBK1006-03 LWW-Govindan-Review November 24, 2011 11:19

Chapter 3•Etiology of Cancer Part 1 35

Question 3.9. Retinoblastoma protein, Rb1, is characterized by the following, EXCEPT:

A. Involved in maintaining the integrity of the retina

B. A central regulator of cell cycle

C. Binds to E2F transcription proteins

D. A 105-kDa protein that undergoes phosphorylation during cell cycle

Question 3.10. Hereditary nonpolyposis colon cancer (HNPCC) syndrome is character-

ized by:

A. Mutations in genes that regulate cellular proliferation

B. Autosomal-recessive inheritance

C. Greater penetrance in women

D. Mutations in genes that are involved in DNA mismatch repair

Question 3.11. Which of the following is characteristic of HNPCC or Lynch syndrome?

A. HNPCC is inherited in autosomal-dominant pattern with increased

penetrance in males.

B. Multiple polyps are seen on colonoscopy, preceding the diagnosis of

colon cancer.

C. Annual colonoscopy is recommended for family members of patients

with HNPCC, starting at age 40.

D. Patients with HNPCC have germ line mutations in theAPCgene.

Question 3.12. Impaired activity of BRCA 1 and BRCA 2 proteins affects:

A. Repair of double-stranded DNA breaks

B. Cell-cycle regulation

C. Microtubule stabilization

D. Angiogenesis

Question 3.13. BRCA1 mutation carriers typically develop which of the following types

of breast cancer?

A. High grade, ER positive, Her2/neu positive, invasive ductal carci-

noma

B. High grade, ER negative, Her2/neu negative, invasive ductal carci-

noma

C. Low grade, ER positive, Her2/neu negative, invasive ductal carci-

noma

D. Low grade, ER negative, Her2/neu positive, invasive ductal carci-

noma

Question 3.14. All of the following statements regarding neurofibromatosis Type 1(NF1)

are correct, EXCEPT:

A. NF1 is inherited in an autosomal-dominant pattern, with 100% pen-

etrance for neurofibroma.

B. 70 different mutations in NF1 have been reported, most of which

result in a truncated neurofibromin protein.

C. Mutations inSPRED1gene can give rise to an NF1-like phenotype.

D. Genetic testing for NF1 significantly impacts clinical management.