Devita, Hellman, and Rosenberg's Cancer

LWBK1006-03 LWW-Govindan-Review November 24, 2011 11:19

40 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 3.35. The recently approved HPV vaccine:

A. Is a quadrivalent vaccine containing virus-like particles (VLPs) from

four different types of HPV

B. Protects all types of HPV-causing cervical cancer

C. Is recommended for all sexually active men and women

D. Eliminates the need for routine cervical cancer screening 2 years after

completing the vaccination schedule

Question 3.36. The role of EBV in cancer is characterized by the following, EXCEPT:

A. EBV nuclear proteins target transcription factor RBPJk/CBF1.

B. Membrane protein LMP1 activates IKK alpha and enhances cellular

proliferation and survival.

C. Involvement in minority of the gastric cancers.

D. Involvement in all Hodgkin’s lymphoma.

Question 3.37. The risk of KS in patients with HIV is highest:

A. In homosexual men

B. In pediatric patients with AIDS

C. In heterosexual men

D. In patients with AIDS related to blood transfusions

Question 3.38. Human herpes virus 8 (HHV8) infection is characterized by:

A. HHV8 sequences are detected only in tumors of patients with KS who

are HIV positive.

B. Five to seven percent of the US general population is infected with

HHV8.

C. In patients with HIV, coinfection with EBV infection is necessary for

development of KS.

D. HHV8 infection is transmitted only through sexual contact.

Question 3.39. The role of polyomaviruses in human cancers is characterized by:

A. A double-blind study has confirmed the correlation of SV40 with

human cancers.

B. SV40 DNA or antigen has been observed in some human cancers,

such as osteosarcomas, mesotheliomas, and brain tumors.

C. BK and JC viruses are recognized etiologic factors in human brain

tumors.

D. Epidemiologic data have confirmed the association of SV40-

contaminated polio vaccines with human cancers.