229
of the esophagus and of the gastric cardia. Am
J Pathol 158(1):33–40. https://doi.
org/10.1016/s0002-9440(10)63941-7
- Onwuegbusi BA, Aitchison A, Chin SF,
Kranjac T, Mills I, Huang Y, Lao-Sirieix P,
Caldas C, Fitzgerald RC (2006) Impaired
transforming growth factor beta signalling
in Barrett’s carcinogenesis due to frequent
SMAD4 inactivation. Gut 55(6):764–774.
https://doi.org/10.1136/gut.2005.
076430
- Agrawal N, Jiao Y, Bettegowda C, Hutfless
SM, Wang Y, David S, Cheng Y, Twaddell WS,
Latt NL, Shin EJ, Wang LD, Wang L, Yang W,
Velculescu VE, Vogelstein B, Papadopoulos N,
Kinzler KW, Meltzer SJ (2012) Comparative
genomic analysis of esophageal adenocarci-
noma and squamous cell carcinoma. Cancer
Discov 2(10):899–905. https://doi.
org/10.1158/2159-8290.cd-12-0189
- Wang X, Li X, Cheng Y, Sun X, Sun X, Self S,
Kooperberg C, Dai JY (2015) Copy number
alterations detected by whole-exome and
whole-genome sequencing of esophageal ade-
nocarcinoma. Hum Genomics 9:22. https://
doi.org/10.1186/s40246-015-0044-0
Single Gene Mutation in Esophageal Adenocarcinoma