vEsophageal adenocarcinoma is highly prevalent in the Western world, and the incidence is
rapidly rising. In addition, esophageal adenocarcinoma is a major cause of cancer-related
morbidity and mortality. Esophageal Adenocarcinoma: Methods and Protocols provides a
unique comprehensive review of clinical, pathological, and research information for the
management of patients with esophageal adenocarcinoma.
This book starts with an introduction of the basic features of esophageal adenocarci-
noma, followed by clinical protocols for the management of the cancer (radiotherapy, che-
motherapy, target therapy, and surgery). The next major portion of the book highlights the
pathological methods for the management of the patients and research in esophageal ade-
nocarcinoma (histopathology, processing of surgical resection, processing of endoscopic
resection, staging, whole slide scanning, tissue microarray, and study of HER2 marker for
target therapy). The other portion of the book provides protocols for molecular research
(animal models, stem cell works, circulating tumor cells and DNA, DNA studies, RNA
studies, and proteomics). These molecular techniques could help in further understanding
pathogenesis as well as in identifying new targets for the treatment and prevention of
adenocarcinoma.
This is the first time that a book has provided an all-inclusive review and protocols on
the topic of esophageal adenocarcinoma suitable for medical, health, and science profes-
sionals working on the subject. We hope the topics in this book are useful and stimulate
specialists from various disciplines to continue their research in esophageal adenocarci-
noma. In addition, promoting the research in this area will translate to improving the man-
agement of this cancer of rising importance.
I thank all the authors as well as staff in my research team for their invaluable
contribution.
Gold Coast, Australia Alfred K. Lam
Preface