Esophageal Adenocarcinoma Methods and Protocols

vii

Contents

Preface ............................................................................................................................. v
Contributors .................................................................................................................... ix

1 Introduction: Esophageal Adenocarcinoma: Updates of Current Status .............. 1
Alfred K. Lam

2 Radiotherapy for Esophageal Adenocarcinoma ................................................... 7
Dora L. W. Kwong and K. O. Lam

3 Chemotherapy for Esophageal Adenocarcinoma ................................................. 19
Ka-On Lam and Dora L. W. Kwong

4 Surgical Protocol for Esophageal Adenocarcinoma ............................................. 35
Simon Law

5 Target Therapy for Esophageal Adenocarcinoma ................................................ 51
Ka-On Lam and Dora L. W. Kwong

6 Histopathological Assessment for Esophageal Adenocarcinoma .......................... 67
Alfred K. Lam

7 Macroscopic Assessment and Cut Up of Endoscopic Resection
Specimens forEarly Esophageal Glandular Malignancies ...................................... 77
Benjamin M. Allanson and M. Priyanthi Kumarasinghe

8 Processing of Surgical Specimen (Esophagogastrectomy)
for Esophageal Adenocarcinoma ......................................................................... 85
Benjamin M. Allanson and M. Priyanthi Kumarasinghe

9 Application of Pathological Staging in Esophageal Adenocarcinoma ................... 93
Alfred K. Lam

10 Application of Tissue Microarray in Esophageal Adenocarcinoma ....................... 105
Nassim Saremi and Alfred K. Lam

11 Predictive Marker: HER2 in Esophageal Adenocarcinoma .................................. 119
Duminda Subasinghe, Nathan Acott, and M. Priyanthi Kumarasinghe

12 Whole-Slide Imaging for Esophageal Adenocarcinoma ....................................... 135
Alfred K. Lam and Melissa Leung

13 Animal Model: Reflux Models in Esophageal Adenocarcinoma ........................... 143
Takahiro Masuda and Sumeet K. Mittal

14 Animal Model: Xenograft Mouse Models in Esophageal Adenocarcinoma .......... 151
Md Sazzad Hassan and Urs von Holzen

15 Identification of Cancer Stem Cells in Esophageal Adenocarcinoma .................... 165
Farhadul Islam, Vinod Gopalan, and Alfred K. Lam

16 Circulatory Tumor Cells in Esophageal Adenocarcinoma .................................... 177
Vinod Gopalan and Alfred K. Lam