Cannabinoids

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180 V. Marzo et al.


Lastres-Becker I, Fezza F, Cebeira M, Bisogno T, Ramos JA, Milone A, Fernandez-Ruiz J, Di
Marzo V (2001) Changes in endocannabinoid transmission in the basal ganglia in a rat
model of Huntington’s disease. Neuroreport 12:2125–2129
Lichtman AH, Hawkins EG, Griffin G, Cravatt BF (2002) Pharmacological activity of fatty
acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo.
J Pharmacol Exp Ther 302:73–79
Ligresti A, Bisogno T, Matias I, De Petrocellis L, Cascio MG, Cosenza V, D’argenio G,
Scaglione G, Bifulco M, Sorrentini I, Di Marzo V (2003) Possible endocannabinoid
control of colorectal cancer growth. Gastroenterology 125:677–687
Ligresti A, Morera E, Van Der Stelt MM, Monory K, Lutz B, Ortar G, Di Marzo V (2004)
Furtherevidencefortheexistenceofaspecificprocessforthemembranetransportof
anandamide. Biochem J 380(Pt 1):265–272
Liu J, Batkai S, Pacher P, Harvey-White J, Wagner JA, Cravatt BF, Gao B, Kunos G (2003)
Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/
phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. J Biol
Chem 278:45034–45039
Liu Q, Tonai T, Ueda N (2002) Activation of N-acylethanolamine-releasing phospholipase
D by polyamines. Chem Phys Lipids 115:77–84
Lopez-Rodriguez ML, Viso A, Ortega-Gutierrez S, Lastres-Becker I, Gonzalez S, Fernandez-
Ruiz JJ, Ramos, JA (2001) Design, synthesis and biological evaluation of novel arachi-
donic acid derivatives as highly potent and selective endocannabinoid transporter in-
hibitors. J Med Chem 44:4505–4508
Lopez-Rodriguez ML, Viso A, Ortega-Gutierrez S, Fowler CJ, Tiger G, de Lago E, Fernandez-
Ruiz J, Ramos JA (2003a) Design, synthesis and biological evaluation of new endo-
cannabinoid transporter inhibitors. Eur J Med Chem 38:403–412
Lopez-Rodriguez ML, Viso A, Ortega-Gutierrez S, Fowler CJ, Tiger G, de Lago E, Fernandez-
Ruiz J, Ramos JA (2003b) Design, synthesis, and biological evaluation of new inhibitors
of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase.
J Med Chem 46:1512–1522
Maccarrone M, Bari M, Lorenzon T, Bisogno T, Di Marzo V, Finazzi-Agrò A (2000a) Anan-
damide uptake by human endothelial cells and its regulation by nitric oxide. J Biol Chem
275:13484–13492
Maccarrone M, Salvati S, Bari M, Finazzi-Agrò A (2000b) Anandamide and 2-arachidonoyl-
glycerol inhibit fatty acid amide hydrolase by activating the lipoxygenase pathway of the
arachidonate cascade. Biochem Biophys Res Commun 278:576–583
Maccarrone M, Valensise H, Bari M, Lazzarin N, Romanini C, Finazzi-Agro’ A (2000c) Rela-
tion between decreased anandamide hydrolase concentrations in human lymphocytes
and miscarriage. Lancet 355:1326–1329
Maccarrone M, De Petrocellis L, Bari M, Fezza F, Salvati S, Di Marzo V, Finazzi-Agrò A
(2001) Lipopolysaccharide downregulates fatty acid amide hydrolase expression and
increases anandamide levels in human peripheral lymphocytes. Arch Biochem Biophys
393:321–328
Maccarrone M, Bisogno T, Valensise H, Lazzarin N, Fezza F, Manna C, Di Marzo V, Finazzi-
Agro’ A (2002a) Low fatty acid amide hydrolase and high anandamide levels are associ-
ated with failure to achieve an ongoing pregnancy after IVF and embryo transfer. Mol
Hum Reprod 8:188–195
MaccarroneM,CartoniA,ParolaroD,MargonelliA,MassiP,BariM,BattistaN,Finazzi-Agrò
A (2002b) Cannabimimetic activity, binding, and degradation of stearoylethanolamide
within the mouse central nervous system. Mol Cell Neurosci 21:126–140
Maccarrone M, Bari M, Di Rienzo M, Finazzi-Agrò A, Rossi A (2003a) Progesterone activates
Fatty Acid Amide Hydrolase (FAAH) promoter in Human T lymphocytes through the
transcription factor Ikaros: evidence for a synergistic effect of leptin. J Biol Chem
278:32726–32732

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