Cannabinoids

Effects of Cannabinoids on Neurotransmission 333

Table 1.

Inhibition of glutamatergic neurotransmission (

continuedonnextpage

)

Neurotransmitter Species

Region

Method

Mechanism of presynaptic inhibition

Reference(s)

Glutamate

Rat

Cortex (brain slice)

Electrophysiology

(patch clamp) Vesicle release machinery inhibited

Auclair et al. 2000

Glutamate

a

Rat

Cortex (cell culture) Endogenous glutamate

chemically determined

IP^3

is involved

Ferraro et al. 2001

Glutamate

Rat

Caudate-putamen(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Gerdemanand Lovinger 2001

Glutamate

Rat

Caudate-putamen(brain slice)

Electrophysiology (patch clamp,extracell. recording)

The inhibition is pertussis toxin sensitiveVesicle release machinery not inhibited

Huang et al. 2001, 2002

Ca

2+

channels involved

Glutamate

Rat

Caudate-putamen(brain slice)

Electrophysiology(extracell. recording),^3 [

H]glutamate release

Glutamate uptake is inhibited, glutamatecauses presynaptic inhibition via mGluR

Brown et al. 2003b

Glutamate

Mouse

Nucleus accumbens(brain slice)

Electrophysiology (patch clamp,extracell. recording)

Vesicle release machinery inhibitedCa

2+

channels not involved

+K

channels involved

cAMP and PKA not involved

Robbe et al. 2001

Glutamate

Mouse

Globus pallidus(brain slice)

Electrophysiology (patch clamp) No details given

Wallmichrathand Szabo 2003

Glutamate

Rat

Ventral tegmentalarea

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Melis

et al. 2004

Glutamate

Rat

Substantia nigrapars reticulata(brain slice)

Electrophysiology (patch clamp) No details given

Szabo et al. 2000

Glutamate

Rat

Hippocampus(brain slice)

Electrophysiology(extracell. recording)

No details given

Ameri et al. 1999;Ameri and Simmet 2000

Glutamate

Rat

Hippocampus(brain slice)

Electrophysiology(extracell. recording)

No details given

Al-Hayani and Davies 2000