Cannabinoids

338 B. Szabo and E. Schlicker

Table 2.

Inhibition of GABAergic neurotransmission (

continuedonnextpage

)

Neurotransmitter Species

Region

Method

Mechanism of presynaptic inhibition

Reference(s)

GABA

Mouse

Cortex (brain slice)

Electrophysiology (patch clamp)

Vesicle release machinery not inhibited

Trettel and Levine2002, 2003

GABA

Rat

Caudate-putamen(brain slice)

Electrophysiology (patch clamp) No details given

Szabo et al. 1998

GABA

Mouse

Nucleus accumbens(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery inhibited

Manzoni and Bockaert 2001

GABA

Rat

Nucleus accumbens(brain slice)

Electrophysiology (patch clamp) Vesiclereleasemachineryweaklyinhibited Hoffman

and Lupica 2001;

Hoffman et al. 2003a

GABA

Mouse

Globus pallidus(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery not inhibited

Engler

andSzabo2003,2004

GABA

Rat

Substantia nigrapars reticulata(brain slice)

Electrophysiology (patch clamp) No details given

Chan et al. 1998,Chan and Yung 1998

GABA

Rat

Substantia nigrapars reticulata(brain slice)

Electrophysiology (patch clamp) No details given

Wallmichrathand Szabo 2002a

GABA

Mouse

Substantia nigrapars reticulata(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery not inhibited

Wallmichrathand Szabo 2002b

GABA

Rat

Ventral tegmentalarea (brain slice)

Electrophysiology (patch clamp) Vesicle release machinery not inhibited

Szabo et al. 2002

GABA(GABA

-mediatedB

transmission)

Rat

Ventral tegmentalarea (brain slice)

Electrophysiology (patch clamp) No details given

Riegel et al. 2003

GABA

Rat

Hippocampus(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery not inhibited

Hájos

et al. 2000

GABA

Rat

Hippocampus(brain slice)

Electrophysiology (patch clamp) Vesicle release machinery not inhibited

+K

channels not involved

Hoffman and Lupica 2000