Effects of Cannabinoids on Neurotransmission 347Table 4.
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NeurotransmitterSpeciesTissueMethodReference(s)Acetylcholine, ATPMouseUrinary bladderElectrically evoked contractionPertwee and Fernando 1996Acetylcholine,NANC-transmitterMouseColonElectrically evoked cholinergic and NANCpostsynaptic potentialsStorr et al. 2004AcetylcholineGuinea-pig IleumElectrically evoked contraction, acetylcholinerelease, cholinergic postsynaptic potentialsPertwee et al. 1992, 1996b; Lopez-Redondo et al. 1997; Mang et al. 2001Acetylcholine,NANC-transmitterGuinea-pig IleumElectrically evoked contractionIzzo et al. 1998AcetylcholineManIleumElectrically evoked contractionCroci et al. 1998AdenosineGuinea-pig IleumElectrically evoked adenosine releaseBegg et al. 2002CGRPRatPrimary sensory neurons(cell culture)Basal and capsaicin-evoked CGRP releaseAhluwalia et al. 2003CGRP, substance P,somatostatinRatTracheaCapsaicin-evoked CGRP, substance Pand somatostatin releaseNemeth et al. 2003CGRPRatHind paw skinCapsaicin-evoked CGRP releaseRichardson et al. 1998;Ellington et al. 2002CGRPRatSpinal cord slicesElectrically evoked CGRP releaseTognetto et al. 2001CGRP, calcitonin gene-related peptide; NANC, non-adrenergic-non-cholinergic