Effects of Cannabinoids on Neurotransmission 365Vaughan CW, Connor M, Bagley EE, Christie MJ (2000) Actions of cannabinoids on mem-
brane properties and synaptic transmission in rat periaqueductal gray neurons in vitro.
Mol Pharmacol 57:288–295
Verrico CD, Jentsch JD, Dazzi L, Roth RH (2003) Systemic, but not local, administration of
cannabinoid CB1 receptor agonists modulate prefrontal cortical acetylcholine efflux in
the rat. Synapse 48:178–183
Vizi ES, Katona I, Freund TF (2001) Evidence for presynaptic cannabinoid CB 1 receptor-
mediated inhibition of noradrenaline release in the guinea pig lung. Eur J Pharmacol
431:237–244
Wallmichrath I, Szabo B (2002a) Analysis of the effect of cannabinoids on GABAergic
neurotransmissioninthesubstantianigraparsreticulata.Naunyn–Schmiedeberg’sArch
Pharmacol 365:326–334
Wallmichrath I, Szabo B (2002b) Cannabinoids inhibit striatonigral GABAergic neurotrans-
mission in the mouse. Neuroscience 113:671–682
Wallmichrath I, Szabo B (2003) Effects of cannabinoids on the glutamatergic neurotrans-
mission between nucleus subthalamicus and globus pallidus. Naunyn–Schmiedeberg’s
Arch Pharmacol 367:R83
Wang S-J (2003) Cannabinoid CB 1 receptor-mediated inhibition of glutamate release from
rat hippocampal synaptosomes. Eur J Pharmacol 469:47–55
Wilson RI, Nicoll RA (2001) Endogenous cannabinoids mediate retrograde signalling at
hippocampal synapses. Nature 410:588–592
Wilson RI, Nicoll RA (2002) Endocannabinoid signaling in the brain. Science 296:678–682
Wu L-G, Saggau P (1997) Presynaptic inhibition of elicited neurotransmitter release. Trends
Neurosci 20:204–212
Yoshida T, Hashimoto K, Zimmer A, Maejima T, Araishi K, Kano M (2002) The cannabinoid
CB1 receptor mediates retrograde signals for depolarization-induced suppression of
inhibition in cerebellar Purkinje cells. J Neurosci 22:1690–1697
Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI (1999) Increased mor-
tality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc
Natl Acad Sci USA 96:5780–5785
ZygmuntPM,PeterssonJ,AnderssonDA,ChuangH,SorgardM,DiMarzoV,JuliusD,
Högestätt ED (1999) Vanilloid receptors on sensory nerves mediate the vasodilator
action of anandamide. Nature 400:452–457