548 J.M. Walker and A.G. Hohmann
Hohmann AG, Tsou K, Walker JM (1999b) Cannabinoid suppression of noxious heat-evoked
activity in wide dynamic range neurons in the lumbar dorsal horn of the rat. J Neuro-
physiol 81:575–583
Hohmann AG, Tsou K, Walker JM (1999c) Intrathecal cannabinoid administration sup-
presses noxious-stimulus evoked Fos protein-like immunoreactivity in rat spinal cord:
comparison with morphine. Acta Pharmacol Sin 20:1132–1136
Hohmann AG, Neely MH, Suplita RL, Nackley AG, Holmes PV, Crystal JD (2001) Endo-
cannabinoid mechanisms of stress-induced analgesia. Soc Neurosci Abstr 27:716–719
Hohmann AG, Farthing JN, Zvonok AM, Makriyannis A (2004) Selective activation of
cannabinoid CB2 receptors suppresses hyperalgesia evoked by intradermal capsaicin.
J Pharmacol Exp Ther 308:446–453
HuangSM,BisognoT,TrevisaniM,Al-HayaniA,DePetrocellisL,FezzaF,TognettoM,
Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V
(2002) An endogenous capsaicin-like substance with high potency at recombinant and
native vanilloid VR1 receptors. Proc Natl Acad Sci U S A 99:8400–8405
Hunt SP, Pini A, Evan G (1987) Induction of c-fos-like protein in spinal cord neurons
following sensory stimulation. Nature 328:632–634
Ibrahim MM, Deng H, Zvonok A, Cockayne DA, Kwan J, Mata HP, Vanderah TW, Lai J,
Porreca F, Makriyannis A, Malan TP (2003) Activation of CB2 cannabinoid receptors
by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not
present in the CNS. Proc Natl Acad Sci USA 100:10529–10533
Jennings EA, Vaughan CW, Christie MJ (2001) Cannabinoid actions on rat superficial
medullary dorsal horn neurons in vitro. J Physiol 534:805–812
Ji RR, Zhang X, Wiesenfeld-Hallin Z, Hokfelt T (1994) Expression of neuropeptide Y and
neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following
peripheral tissue inflammation. J Neurosci 14:6423–6434
Ji RR, Zhang X, Zhang Q, Dagerlind A, Nilsson S, Wiesenfeld-Hallin Z, Hokfelt T (1995)
Central and peripheral expression of galanin in response to inflammation. Neuroscience
68:563–576
Johanek LM, Simone DA (2004) Activation of peripheral cannabinoid receptors attenuates
cutaneous hyperalgesia produced by a heat injury. Pain 109:432–442
Johanek LM, Heitmiller DR, Turner M, Nader N, Hodges J, Simone DA (2001) Cannabinoids
attenuate capsaicin-evoked hyperalgesia through spinal and peripheral mechanisms.
Pain 93:303–315
Karst M, Salim K, Burstein S, Conrad I, Hoy L, Schneider U (2003) Analgesic effect of the
synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial.
JAMA 290:1757–1762
Kelly S, Chapman V (2001) Selective cannabinoid CB1 receptor activation inhibits spinal
nociceptive transmission in vivo. J Neurophysiol 86:3061–3064
Kemp T, Spike RC, Watt C, Todd AJ (1996) The mu-opioid receptor (MOR1) is mainly
restricted to neurons that do not contain GABA or glycine in the superficial dorsal horn
of the rat spinal cord. Neuroscience 75:1231–1238
Kenins P (1982) Responses of single nerve fibres to capsaicin applied to the skin. Neurosci
Lett 29:83–88
Khasabova IA, Simone DA, Seybold VS (2002) Cannabinoids attenuate depolarization-
dependent Ca2+ influx in intermediate-size primary afferent neurons of adult rats.
Neuroscience 115:613–625
Klegeris A, Bissonnette CJ, McGeer PL (2003) Reduction of human monocytic cell neuro-
toxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. Br
J Pharmacol 139:775–786
Ko MC, Woods JH (1999) Local administration of delta9-tetrahydrocannabinol attenuates
capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid
action. Psychopharmacology (Berl) 143:322–326