Cannabinoids

Pharmacological Actions of Cannabinoids 51

Walker JM, Krey JF, Chu CJ, Huang SM (2002) Endocannabinoids and related fatty acid
derivatives in pain modulation. Chem Phys Lipids 121:159–172
Walter L, Franklin A, Witting A, Wade C, Xie Y, Kunos G, Mackie K, Stella N (2003)
Nonpsychotropic cannabinoid receptors regulate microglial cell migration. J Neurosci
23:1398–1405
White R, Hiley CR (1998) The actions of the cannabinoid receptor antagonist, SR 141716A,
in the rat isolated mesenteric artery. Br J Pharmacol 125:689-696
WileyJL,MartinBR(2002)Cannabinoidpharmacology:implicationsforadditionalcannabi-
noid receptor subtypes. Chem Phys Lipids 121:57–63
Wiley JL, Martin BR (2003) Cannabinoid pharmacological properties common to other
centrally acting drugs. Eur J Pharmacol 471:185–193
Wiley JL, Beletskaya ID, Ng EW, Dai Z, Crocker PJ, Mahadevan A, Razdan RK, Martin BR
(2002) Resorcinol derivatives: a novel template for the development of cannabinoid
CB1/CB2 and CB2-selective agonists. J Pharmacol Exp Ther 301:679–689
WrobleskiST,ChenP,HynesJ,LinS,NorrisDJ,PanditCR,SpergelS,WuH,TokarskiJS,
Chen X, Gillooly KM, Kiener PA, McIntyre KW, Patil-Koota V, Shuster DJ, Turk LA, Yang
G, Leftheris K (2003) Rational design and synthesis of an orally active indolopyridone as
a novel conformationally constrained cannabinoid ligand possessing antiinflammatory
properties. J Med Chem 46:2110–2116
Yao L, Fan P, Jiang Z, Mailliard WS, Gordon AS, Diamond I (2003) Addicting drugs utilize

a synergistic molecular mechanism in common requiring adenosine and Gi-βγdimers.

Proc Natl Acad Sci USA 100:14379–14384

Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sφrgård M, Di Marzo V, Julius D,

Högestätt ED (1999) Vanilloid receptors on sensory nerves mediate the vasodilator

action of anandamide. Nature 400:452–457

Zygmunt PM, Andersson DA, Högestätt ED (2002)∆9-tetrahydrocannabinol and cannabinol

activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-

independent mechanism. J Neurosci 22:4720–4727