Synthetic Biology Parts, Devices and Applications

403

Synthetic Biology: Parts, Devices and Applications, First Edition. Edited by Christina Smolke.
© 2018 Wiley-VCH Verlag GmbH & Co. KGaA. Published 2018 by Wiley-VCH Verlag GmbH & Co. KGaA.

a
adoptive T‐cell therapy 352–353
alternative splicing
auxiliary regulatory element 139
controlled splicing in S. cerevisiae 145
and disease 144
events in mammalian
transcripts 138
mechanisms 137
and nonsense mediated decay 143
regulation mechanism 140
transcription‐coupled alternative
splicing 142
antibodies 318
antimicrobial peptides 225
aptamers 181, 198, 262, 267
aptazyme‐regulated expression devices
(aREDs) 199, 205
array synthesis 8, 10
gene assembly on 8

b
bacterial microcompartments
(BMCs) 283–284
Biobrick‐like assembly strategy 337
BioBricks Foundation (BBF) 393
biogenesis 282, 289
biological chassis 50
Biological Innovation for an Open
Society (BIOS) 393
biological technologies
array synthesis 8, 10
genetic instruction sets 10
Moore’s Law 5–6
other technologies 6

pricing improvements in 7–8

productivity improvements in 3, 5

BMCs see bacterial microcompartments

(BMCs)

c

carbohydrate mimicking peptides

(CMPs) 225

carbon catabolite repression 115

CARs 351

catabolic BMCs 283

cell‐free protein synthesis (CFPS) 311

advantages for cell‐free biology 310

antibodies 318

future aspects 321

genetic circuit optimization 321

glycosylation 316

in vitro genetic circuits 321

membrane proteins 318–319

non‐canonical amino acids 316

prokaryotic platforms 311

protein production and

screening 317, 320

trends 312, 314

cellular chassis 50

cellular immunotherapy

CAR for adoptive T‐cell therapy 352

generation of safer T‐cell

therapeutics 359

immune‐system 352

T‐cell therapeutic function 357

CFPS see cell‐free protein synthesis

(CFPS)

chimeric antigen receptors (CARs)

351–352

Index