111Table 4.3Change from baseline for patient-reported outc omes in 4 treat-to-target studiesStudyTargetTender J. countPain score (VAS: 0–100)Patient global assessment (VAS: 0–100)Fatigue score (VAS: 0–100)Morning stiffness (min) HAQ (0–3)TICORA [74]DAS < 2.4−12−43−52NRNR−0.8CAMERA [75]ACR remission−11−36−32NR−63−0.4ESPOIR- GUEPARD [76]DAS- 28 < 3.2−10.1−44.8−46.6−37.1NR−0.9Schipper et al. [77]DAS- 29 < 2.6−4−30−32NRNR−0.5Values are expressed as mean difference from baseline,NRnot reported,VASvisual analogue scale,TICORATight Control for Rheumatoid Arthritis,CAMERAComputer-Assisted Management in Early Rheumatoid Arthritis4 PROMs for Rheumatoid Arthritis