Patient_Reported_Outcome_Measures_in_Rheumatic_Diseases

9- to 10-Year Survival According to Quantitative Markers in Three Chronic Diseases

a

100

80

6

40

20

0 20 40 60 80 100

>90%

81%–90%

71%–80%

£70%

Survival

(%)

(Pincus et al, 1987)

% Activities

“With Ease”

Rheumatoid Arthritis:

Activities of Daily Living

Years

20

40

60

80

Months

100

02468

Survival (%)

10

Stage I

Survival (%)

Stage II

All Stages,

All Causes

Stage III

Stage IV

(Kaplan, 1972)

Hodgkin’s disease:

• Anatomic Stage

c

b Rheumatoid Arthritis –

Formal Education Level

20

40

60

80

100

0 20 40 60 80 100

Months

£8 Years

9–12 Years

>12 Years

Survival (%)

(Pincus et al, 1987)

Years

20

40

60

80

100

8

(Proudfit et al, 1978)

0246 10

d Coronary Artery Disease –

# of Involved Vessels

Fig. 3.2 9- to 10-year survival according to quantitative markers in 3 chronic diseases: ( a, b )
rheumatoid arthritis, ( c ) Hodgkin’s Disease, and ( d ) coronary artery disease

Significant in multivariate analyses Significant in univariate analyses Not Significant

100% 6% 4% 34% 17% 32% 23% 50% 39%

75%

50%

25%

0%

Physical

function

(N=18)

CO-

morbidities

(N=23)

Rheum-

atoid

factor

(N=29)

Extra-

articular

disease

(N=18)

ESR

(N=19)

Socio-

economic

status

(N=13)

Joint

count

(N=18)

Hand

radio-

graph

(N=18)

22% 30%

21% 39% 32% 46%

28%

50%

72% 65% 45% 44% 37% 31% 22% 11%

Fig. 3.3 Signifi cance of 8 variables as predictors of mortality, in a review of 84 reports concerning
mortality in RA, 53 cohorts presented predictors of mortality. For each variable, n = the number of
reports that included the variable, and bars indicate the percentage of those reports in which the
variable was a signifi cant predictor of mortality in multivariate analyses ( black ), in univariate
analyses ( dotted ), or not signifi cant ( white )