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77. What are the treatment strategies for lipodystrophic diabetes?

Recombinant leptin therapy is the most effective treatment for lipodystrophic

diabetes as it targets leptin deficiency, the key pathophysiological defect in

these disorders. The use of recombinant leptin therapy not only improves meta-

ab

c

Fig 12.6 An adolescent with congenital generalized lipodystrophy

12 Diabetes in the Young