Tissue Engineering And Nanotheranostics

(Steven Felgate) #1

“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics


Directed Differentiation of Human Pluripotent Stem Cells 99

formation of visceral yolk sac, blood islands and myocardium. J. Embryol.
Exp. Morphol. 87 , 27–45 (1985).


  1. Xu C, Police S, Rao N, Carpenter MK. Characterization and enrichment
    of cardiomyocytes derived from human embryonic stem cells. Circ. Res.
    91 , 501–508 (2002).

  2. Laflamme MA, et al. Formation of human myocardium in the rat heart
    from human embryonic stem cells. Am. J. Pathol. 167 , 663–671 (2005).

  3. Laflamme MA, et al. Cardiomyocytes derived from human embryonic
    stem cells in pro-survival factors enhance function of infarcted rat hearts.
    Nat. Biotechnol. 25 , 1015–1024 (2007).

  4. Yang L, et al. Human cardiovascular progenitor cells develop from a KDR+
    embryonic-stem-cell-derived population. Nature 453 , 524–528 (2008).

  5. Paige SL, et al. Endogenous Wnt/Beta-Catenin signaling is required for
    cardiac differentiation in human embryonic stem cells. PLoS One 5 , (2010).

  6. Willems E, et al. Small-molecule inhibitors of the Wnt pathway potently
    promote cardiomyocytes from human embryonic stem cell-derived
    mesoderm. Circ. Res. 109 , 360–364 (2011).

  7. Lian X, et al. Directed cardiomyocyte differentiation from human pluri-
    potent stem cells by modulating Wnt/β-catenin signaling under fully
    defined conditions. Nat. Protoc. 8 , 162–75 (2013).

  8. Lian X, et al. Robust cardiomyocyte differentiation from human pluri-
    potent stem cells via temporal modulation of canonical Wnt signaling.
    Proc. Natl. Acad. Sci. 109 , E1848–E1857 (2012).

  9. Kaufman DS, Hanson ET, Lewis RL, Auerbach R, & Thomson JA.
    Hematopoietic colony-forming cells derived from human embryonic
    stem cells. Proc. Natl. Acad. Sci. USA. 98 , 10716–10721 (2001).

  10. Choi K, et al. Hematopoietic and endothelial differentiation of human
    induced pluripotent stem cells. Stem Cells 27 , 559–567 (2009).

  11. Chadwick K, et al. Cytokines and BMP-4 promote hematopoietic
    differentiation of human embryonic stem cells. Blood 102 , 906–915
    (2003).

  12. Pick M, Azzola L, Mossman A, Stanley EG, Elefanty AG. Differentiation
    of human embryonic stem cells in serum-free medium reveals distinct
    roles for bone morphogenetic protein 4, vascular endothelial growth
    factor, stem cell factor, and fibroblast growth factor 2 in hematopoiesis.
    Stem Cells 25 , 2206–2214 (2007).

  13. Woods N-B, et al. Brief report: Efficient generation of hematopoietic
    precursors and progenitors from human pluripotent stem cell lines. Stem
    Cells 29 , 1158–1164 (2011).

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