b2815 Tissue Engineering and Nanotheranostics “9.61x6.69”130 Tissue Engineering and Nanotheranostics
3.1. Multifunctional MRI MNHs
In recent years, the synthesis trend of superparamagnetic nanoparti-
cles (Fe 3 O 4 ) hybrid with paramagnetic nanoparticles or ion (Gd, Mn)
has been rising to obtain dual modality MR imaging. Lou et al. fab-
ricated the core of iron oxide for T 2 MR imaging and Gd 2 O 3 shell for
T 1 -weighted-images in comparison to water as shown in Fig. 20.^104
Fig. 20. (a) Graphical, TEM image, T 1 - and T 2 -weighted MRI color coded images
of Fe 3 O 4 /SiO 2 /Gd 2 O(CO 3 ) 2 core–shell NPs: 200 μM (Gd) for T 1 image, 100 μM
(Fe) for T 2 images as compare to water. (b) T 1 - and T 2 -weighted in vivo MR images
of tumors before and after 10 min and 30 min intravenous injection of FeMn(SiO 4 ).
(c) T 1 – and T 2 -weighted MR imaging of abdomen of nude mouse pre and 1 h post-
intravenous injection of Fe 3 O 4 NPs (right) and Fe 3 O 4 –MnO MHNPs (middle).
Reprinted with permission from Refs. 82, 104 and 105.