b2815 Tissue Engineering and Nanotheranostics “9.61x6.69”134 Tissue Engineering and Nanotheranostics
54.691 mM^1 s^1 , respectively, resulting in these magnetic composites
having high T 2 effect. The prepared Fe 3 O 4 –TiO 2 NPs showed very
good T 2 -weighted MRI performance as compared to water and T 1
images shown in Figs. 22(a) and 22(b). They also observed the PDT
effect using the UV irradiation light on MCF-7 cell line with and
without nanocomposites. The cell viability was examined to be more
than 90% in the absence of nanoparticles. However, viability reduced
to 35% after 15 min of UV-irradiation in the presence of Nanoparticles
(Fig. 22(c)). As a result, Fe 3 O 4 –TiO 2 magnetic nanohybrids are sig-
nificant agents for MRI diagnosis and PDT of cancer.
3.3. Multifunctional MRI and PTT MNHs
The complex MHNPs were reported by Lin et al. to obtain the trimo-
dality anticancer therapy function such as chemotherapy, PDT and PTT.
Fig. 22. (a) and (b) T 1 and T 2 MR images of Fe 3 O 4 –TiO 2 magnetic nanocomposites,
(c) Cell viability after UV light irradiation on MCF-cells with Fe 3 O 4 –TiO 2 nanocom-
posites preferred time and (d) MCF-7 cells without Fe 3 O 4 –TiO 2 nanocomposites.
Reprinted with permission from Ref. 75.^