Tissue Engineering And Nanotheranostics

“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics

Magnetic Nanohybrids for Magnetic Resonance Imaging 135

The structure is given in Fig. 23(a).^54 Here, we are considering MRI

and PDT part. GdOF:Ln@SiO 2 –ZnPc–CDs microcapsules were injected

to the H22 tumor-bearing mice at the tumor place and the results of

different groups are shown in Fig. 23(b). Remarkable change in the

tumor volume was observed between control and UCMCs–DOX

under NIR irradiation a is shown in Fig. 23(b). After 14 days of treat-

ment, for mice treated with UCMCs–DOX+NIR, that tumor size did

not only stop growing but also decreased from original volume as can

be seen in individual tumor size comparison pictures. Further, they

Fig. 23. (a) Representative pictures of mice after various intratumoral treatments:
control, DOX, UCMCs–DOX, UCMCs+NIR irradiation, and UCMCs–DOX+NIR
irradiation. (b) Snaps of tumor tissue attained after 14 days. (c) and (d) In vitro, T 1
and T 2 MRI and corresponding relaxation rate (1/T 1 , 1/T 2 ) with different concen-
trations of Gd. Reprinted with permission from Ref. 54.